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The tissue proteome in the multi-omic landscape of kidney disease
Kidney research is entering an era of ‘big data’ and molecular omics data can provide comprehensive insights into the molecular footprints of cells....
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Metabolic syndrome and the plasma proteome: from association to causation
BackgroundThe metabolic syndrome (MetS), defined by the simultaneous clustering of cardio-metabolic risk factors, is a significant worldwide public...
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Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood
Genome-wide association studies (GWASs) have identified numerous risk genes for depression. Nevertheless, genes crucial for understanding the...
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Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation
BackgroundAminoacyl tRNA-synthetases are ubiquitously-expressed enzymes that attach amino acids to their cognate tRNA molecules. Mutations in several...
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A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A. Restoring UBE3A levels is a potential...
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Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome
Homer1 is a synaptic scaffold protein that regulates glutamatergic synapses and spine morphogenesis. HOMER1 knockout (KO) mice show behavioral...
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Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes
Purpose of the ReviewProteins are the central layer of information transfer from genome to phenome and represent the largest class of drug targets....
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Global proteomic profiling of multiple organs of cats (Felis catus) and proteome-transcriptome correlation during acute Toxoplasma gondii infection
BackgroundToxoplasma gondii is a protozoan parasite which can infect almost all warm-blooded animals and humans. Understanding the differential...
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The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
Granulovacuolar degeneration (GVD) is a common feature in Alzheimer’s disease (AD). The occurrence of GVD is closely associated with that of...
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Differential proteome profile, biological pathways, and network relationships of osteogenic proteins in calcified human aortic valves
Calcific aortic valve disease (CAVD) is the most common heart valve disease requiring intervention. Most research on CAVD has focused on...
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Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis
BackgroundJuvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease...
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Comparative proteomic analysis of mustard lung as a complicated disease using systems biology approach
During Iraq-Iran conflict, chemical weapons, particularly SM gas, were used numerous times, whose aftereffects are still present. This study aimed to...
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Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE
BackgroundThe objective of the study was to explore the disease pathways activated in the inflammatory foci of skin lesions in cutaneous lupus...
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Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria
BackgroundNocturnal enuresis (NE) is a common disease with multiple pathogenic mechanisms. This study aimed to compare levels of metabolites and...
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Whole-transcriptome and proteome analyses identify key differentially expressed mRNAs, miRNAs, lncRNAs and circRNAs associated with HCC
Hepatocellular carcinoma (HCC) is the most common subtype of primary liver cancer and one of the leading causes of cancer-related death worldwide. To...
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Integrative transcriptomic and proteomic analysis reveals mechanisms of silica-induced pulmonary fibrosis in rats
BackgroundSilicosis is a systemic disease characterized by persistent inflammation and incurable pulmonary fibrosis. Although great effort has been...
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Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes
BackgroundKinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors...
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Multiomic study of skin, peripheral blood, and serum: is serum proteome a reflection of disease process at the end-organ level in systemic sclerosis?
BackgroundSerum proteins can be readily assessed during routine clinical care. However, it is unclear to what extent serum proteins reflect the...
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Iron overload is related to muscle wasting in patients with cachexia of gastric cancer: using quantitative proteome analysis
The incidence of gastric cancer cachexia is high and the clinical management is poor, so the study aimed to clarify the mechanism of muscle wasting...
