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Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes
BackgroundMechanistic static pharmacokinetic (MSPK) models are simple, have fewer data requirements, and have broader applicability; however, they...
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An in vivo pharmacokinetic study of metformin microparticles as an oral sustained release formulation in rabbits
BackgroundMetformin hydrochloride is a biguanide derivative that has been widely used to treat type 2 diabetes in humans. In veterinary medicine,...
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Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information
Many machine learning techniques provide a simple prediction for drug-drug interactions (DDIs). However, a systematically constructed database with...
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Prevalence and sort of pharmacokinetic drug–drug interactions in hospitalized psychiatric patients
Psychiatric patients are high-risk patients for the development of pharmacokinetic drug–drug interactions (DDIs), leading to highly variable (victim)...
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Signal Detection and Assessment of Herb–Drug Interactions: Saudi Food and Drug Authority Experience
IntroductionNumerous investigations on herbal medicine that have been undertaken in the past several years demonstrate the general acceptance of its...
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Metabolic profiling and pharmacokinetic studies of Baihu-Guizhi decoction in rats by UFLC-Q-TOF–MS/MS and UHPLC-Q-TRAP-MS/MS
BackgroundBaihu-Guizhi decoction (BHGZD) is a well-documented traditional Chinese Medicine (TCM) prescription that has been extensively applied to...
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Drug Interactions with Antihypertensives
Purpose of ReviewHypertension is remarkably prevalent, affecting an estimated 1.13 billion people worldwide. It often requires the use of multi-drug...
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Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study
BackgroundCardiovascular diseases are responsible for a significant proportion of mortalities worldwide. Elderly patients are the most affected by...
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The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
BackgroundThe concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to...
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Screening for clinically relevant drug-drug interactions between direct oral anticoagulants and antineoplastic agents: a pharmacovigilance approach
BackgroundUse of direct oral anticoagulants (DOACs) in patients with cancer remains suboptimal due to the concern regarding potential drug-drug...
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Screening indicators to evaluate the clinical significance of drug-drug interactions in polypharmacy among older adults with psychiatric disorders: a delphi study
BackgroundPolypharmacy is common in older adults with psychiatric disorders, but no consensus has reached about the reliable indicators evaluating...
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Anti-coagulant Treatment of Cancer-Associated Thrombosis in Frail Patients: Impact of Frailties on the Management of Drug–Drug Interactions
Low molecular weight heparins (LMWH) and anti-Xa direct oral anti-coagulants (DOACs) are recommended for the long-term treatment of cancer-associated...
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Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain–Barré Syndrome
Background and ObjectiveIntravenous immunoglobulin (IVIg) at a standard dosage is the treatment of choice for Guillain–Barré syndrome. The...
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Heart transplantation and human immunodeficiency virus–navigating drug-drug interactions: a case report
BackgroundAntiretroviral therapy (ART) has led to a decline in human immunodeficiency virus (HIV)-related mortality, but comorbidities, including...
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Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients
ObjectivesThe purpose of this study was to assess the impact of polypharmacy, potentially inappropriate medications, and drug-drug interactions on...
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Panitumumab: A Review of Clinical Pharmacokinetic and Pharmacology Properties After Over a Decade of Experience in Patients with Solid Tumors
Panitumumab is a fully human monoclonal antibody that binds to the epidermal growth factor receptor (EGFR), thereby inhibiting the growth and...
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Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion
BackgroundCytochrome P450 (CYP) 3A contributes to the metabolism of many approved drugs. CYP3A perpetrator drugs can profoundly alter the exposure of...
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Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions
Background and ObjectiveAn important barrier to HIV prevention among transgender women (TGW) is the concern that oral pre-exposure prophylaxis (PrEP)...
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Gut microbiota and cardiac arrhythmia: a pharmacokinetic scope
BackgroundDealing with cardiac arrhythmia is a difficult challenge. Choosing between different anti-arrhythmic drugs (AADs) while being cautious...
