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Pharmacological Basis for Abrogating Myocardial Reperfusion Injury Through a Multi-Target Combined Antioxidant Therapy
The main goal of the treatment for acute myocardial infarction is to achieve reperfusion of the affected myocardial tissue, with percutaneous...
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Obesity and atrial fibrillation: a narrative review from arrhythmogenic mechanisms to clinical significance
The prevalence of obesity and atrial fibrillation (AF), which are inextricably linked, is rapidly increasing worldwide. Obesity rates are higher...
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Measurement of superoxide dismutase: clinical usefulness for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis
ObjectiveTo investigate the clinical usefulness of serum superoxide dismutase (SOD) measurement in patients with anti-neutrophil cytoplasmic antibody...
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Immunomodulation of Macrophages May Benefit Cutaneous Leishmaniasis Outcome
Purpose of ReviewThis review emerges from the necessity to gather information of quality on the possibility to directly modulate macrophages and its...
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Hydrogen gas can ameliorate seizure burden during therapeutic hypothermia in asphyxiated newborn piglets
BackgroundWe previously reported that hydrogen (H 2 ) gas combined with therapeutic hypothermia (TH) improved short-term neurological outcomes in...
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NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition
BackgroundPulmonary fibrosis is a progressive and usually lethal pulmonary disease. Despite considerable research efforts, no effective therapeutic...
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Protective effects of inhaled antioxidants against air pollution-induced pathological responses
As the public health burden of air pollution continues to increase, new strategies to mitigate harmful health effects are needed. Dietary...
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Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
BackgroundMechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to...
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In vivo efficacy of silver nanoparticles against Syphacia muris infected laboratory Wistar rats
Helminth infections are a worldwide problem that affects both humans and animals in develo** countries. The common pinworm Syphacia muris ...
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Multifaceted mitochondria in innate immunity
The ability of mitochondria to transform the energy we obtain from food into cell phosphorylation potential has long been appreciated. However,...
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Nox1-derived oxidative stress as a common pathogenic link between obesity and hyperoxaluria-related kidney injury
Specific relationships among reactive oxygen species, activation pathways, and inflammatory mechanisms involved in kidney injury were assessed in a...
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Iron as an emerging therapeutic target in critically ill patients
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis....
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Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
CD40L–CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary heart disease (CHD). We tested the...
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Blunted sympathetic neurovascular transduction is associated to the severity of obstructive sleep apnea
PurposeObstructive sleep apnea (OSA) is a common disorder (~ 4%) that augments sympathetic nerve activity (SNA) and elevates blood pressure. The...
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Air Pollution and Diet: Potential Interacting Exposures in Asthma
Purpose of ReviewTo provide a review of emerging literature describing the impact of diet on the respiratory response to air pollution in asthma.
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The Novel Role of Crocus sativus L. in Enhancing Skin Flap Survival by Affecting Apoptosis Independent of mTOR: A Data-Virtualized Study
BackgroundDespite the improvements to enhance skin flap viability, the effects of ischemia-reperfusion (IR), oxidative stress, necrosis, and...
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Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy
Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead...
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Duchenne muscular dystrophy: pathogenesis and promising therapies
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease, characterized by progressive deterioration of skeletal muscle...
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Iron Dyshomeostasis and Mitochondrial Function in the Failing Heart: A Review of the Literature
Cardiac contraction and relaxation require a substantial amount of energy provided by the mitochondria. The failing heart is adenosine triphosphate...
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Superoxide dismutase isozymes in cerebral organoids from autism spectrum disorder patients
Autism spectrum disorder is a pervasive neurodevelopmental disorder with a substantial contribution to the global disease burden. Despite intensive...
