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PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans
PurposeToludesvenlafaxine is a recently developed antidepressant that belongs to the triple reuptake inhibitor class. Despite the in vitro evidence...
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Quantification of Indoor Respirable Suspended Particulate Matters (RSPM) and Asthma in Rural Children of Delhi-NCR
ObjectivesTo assess the exposure of indoor respirable suspended particulate matters (PM 10 , PM 2.5, and PM 1 ) and their association with asthma in...
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Emergency department crowding increases 10-day mortality for non-critical patients: a retrospective observational study
The current evidence suggests that higher levels of crowding in the Emergency Department (ED) have a negative impact on patient outcomes, including...
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Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the first and the consecutive upsurges of the second wave of the COVID-19 pandemic in the Netherlands
BackgroundTo assess trends in the quality of care for COVID-19 patients at the ICU over the course of time in the Netherlands.
Methods ...
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Proxy methods for detection of inhalation exposure in simulated office environments
BackgroundModern health concerns related to air pollutant exposure in buildings have been exacerbated owing to several factors. Methods for assessing...
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The effect of digitalization of nursing forms in ICUs on time and cost
ObjectiveIntensive Care Units are one of the areas with the lowest digitization rate. This study aims to measure the effect of digitizing medical...
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Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
This article provides an overview of the diagnosis and the treatment of lower urinary tract symptoms in older adults complicated by the...
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Supporting COVID-19 policy-making with a predictive epidemiological multi-model warning system
BackgroundIn response to the SARS-CoV-2 pandemic, the Austrian governmental crisis unit commissioned a forecast consortium with regularly projections...
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Outcomes of discoid excision and segmental resection for colorectal endometriosis: robotic versus conventional laparoscopy
Surgery for deep endometriosis with colorectal involvement is an option after medical treatment failure. Over the past decade, robotic laparoscopy...
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Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase
PurposeCholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting...
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Evaluation of [11C]UCB-A positron emission tomography in human brains
BackgroundIn preclinical studies, the positron emission tomography (PET) imaging with [ 11 C]UCB-A provided promising results for imaging synaptic...
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Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu 2 R and mGlu 3 R) in brains of schizophrenia patients...
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A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting...
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Gut microbial ecology and exposome of a healthy Pakistani cohort
BackgroundPakistan is a multi-ethnic society where there is a disparity between dietary habits, genetic composition, and environmental exposures. The...
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Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels
The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders....
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Unraveling the COVID-19 hospitalization dynamics in Spain using Bayesian inference
BackgroundOne of the main challenges of the COVID-19 pandemic is to make sense of available, but often heterogeneous and noisy data. This...
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Case fatality inequalities of critically ill COVID-19 patients according to patient-, hospital- and region-related factors: a French nationwide study
BackgroundThe COVID-19 sanitary crisis inflicted different challenges regarding the reorganization of the human and logistic resources, particularly...
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SARS-CoV-2 incidence in secondary schools; the role of national and school-initiated COVID-19 measures
IntroductionOur aim was to gain insight into the effect of COVID-19 measures on SARS-CoV-2 incidence in secondary schools and the association with...
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Impact of interventions to reduce nosocomial transmission of SARS-CoV-2 in English NHS Trusts: a computational modelling study
BackgroundPrior to September 2021, 55,000–90,000 hospital inpatients in England were identified as having a potentially nosocomial SARS-CoV-2...
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An Effective Methodology for Scoring to Assist Emergency Physicians in Identifying Overcrowding in an Academic Emergency Department in Thailand
BackgroundEmergency Department (ED) overcrowding is a global concern, with tools like NEDOCS, READI, and Work Score used as predictors. These tools...
