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Mi Puente (My Bridge) Care Transitions Program for Hispanic/Latino Adults with Multimorbidity: Results of a Randomized Controlled Trial
BackgroundMultimorbidity frequently co-occurs with behavioral health concerns and leads to increased healthcare costs and reduced quality and...
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SupportPrim—a computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice: study protocol for a randomized controlled trial
BackgroundMusculoskeletal disorders represented 149 million years lived with disability world-wide in 2019 and are the main cause of years lived with...
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Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial
BackgroundSuboptimal medication use contributes to a substantial proportion of hospitalizations and emergency department visits in older adults. We...
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Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial
BackgroundA significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the...
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Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial
Female suicide attempts peak peri-menstrually—around the onset of menses—when the ovarian steroids estradiol (E2) and progesterone (P4) fall rapidly....
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Surgical treatment of neuromuscular Early Onset Scoliosis with a bilateral posterior one-way rod compared to the Spring Distraction System: study protocol for a limited-efficacy Randomized Controlled Trial (BiPOWR)
BackgroundEarly Onset Scoliosis (EOS) is a progressive spinal deformity in children, and a potentially life-threatening disease. “Growth-friendly”...
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App-Based Addiction Prevention at German Vocational Schools: Implementation and Reach for a Cluster-Randomized Controlled Trial
This article examines the implementation, participation rates, and potential determinants of participation in the digital addiction prevention...
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Increasing palliative care capacity in primary care: study protocol of a cluster randomized controlled trial of the CAPACITI training program
BackgroundPrimary care providers play a critical role in providing early palliative care to their patients. Despite the availability of clinical...
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One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial
This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a...
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Design and Analytic Methods to Evaluate Multilevel Interventions to Reduce Health Disparities: Rigorous Methods Are Available
In June 2022, the NIH Office of Disease Prevention (ODP) issued a Call for Papers for a Supplemental Issue to Prevention Science on Design and...
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Child–Adult Contract for Prevention of Tobacco Use: “As-Treated” Analysis of a Cluster Randomized Controlled Trial (the TOPAS Study) at 3-Year Follow-Up
To estimate the effect of a 3-year commitment to remain tobacco free on tobacco uptake among high school students in Sweden. The commitment is...
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School-based physical activity in relation to active travel – a cluster randomized controlled trial among adolescents enrolled in the school in motion study in Norway
BackgroundActive travel and school settings are considered ideal for promoting physical activity. However, previous research suggests limited effect...
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Study protocol: development and randomized controlled trial of a preventive blended care parenting intervention for parents with PTSD
BackgroundChildren of parents with post-traumatic stress disorder (PTSD) are at increased risk of adverse psychological outcomes. An important risk...
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VR-SOAP, a modular virtual reality treatment for improving social activities and participation of young people with psychosis: a study protocol for a single-blind multi-centre randomized controlled trial
BackgroundYoung people with a psychotic disorder have the same social goals as their healthy peers, but their social networks are smaller, they...
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Technology-assisted cognitive-behavior therapy delivered by peers versus standard cognitive behavior therapy delivered by community health workers for perinatal depression: study protocol of a cluster randomized controlled non-inferiority trial
BackgroundThe lack of trained mental health professionals is a key barrier to scale-up of evidence-based psychological interventions in low and...
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Active versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial
BackgroundAnhedonia, which is defined as the inability to feel pleasure, is considered a core symptom of major depressive disorder (MDD). It can lead...
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Evaluating a scalable ARCHES (Addressing Reproductive Coercion in Health Settings) model in government health facilities in Uasin Gishu county, Kenya: study protocol for a cluster-randomized controlled trial
BackgroundSince 2013, the World Health Organization has recommended that reproductive coercion (RC) and intimate partner violence (IPV) be addressed...
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Behavioral economic and wellness-based approaches for reducing alcohol use and consequences among diverse non-student emerging adults: study protocol for Project BLUE, a randomized controlled trial
BackgroundEmerging adults (EAs) who are not 4-year college students nor graduates are at elevated risk for lifetime alcohol use disorder, comorbid...
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Peers plus mobile app for treatment in HIV (PATH): protocol for a randomized controlled trial to test a community-based integrated peer support and mHealth intervention to improve viral suppression among Hispanic and Black people living with HIV
BackgroundSignificant disparities continue to exist in the HIV care continuum, whereby Hispanic and Black people living with HIV (PLWH) are less...
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A randomized controlled trial of a preventive intervention for the children of parents with depression: mid-term effects, mediators and moderators
BackgroundIn a parallel randomized controlled trial the effectiveness of the family- and group-based cognitive-behavioural “Gug-Auf” intervention in...
