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The role of the motor subtypes on the relationship between anxiety and cognitive dysfunctions in Parkinson’s disease
Anxiety is a common neuropsychiatric symptom in Parkinson’s disease (PD). Until now, anxiety has been consistently related to cognitive deficits and...
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Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study
BackgroundPrevious studies have shown that there is a relationship between cognitive impairment (CI) and motor dysfunction (MD) in neurological...
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α-Synuclein molecular behavior and nigral proteomic profiling distinguish subtypes of Lewy body disorders
Lewy body disorders (LBD), characterized by the deposition of misfolded α-synuclein (α-Syn), are clinically heterogeneous. Although the distribution...
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Non-motor features of essential tremor with midline distribution
BackgroundMidline essential tremor (Mid-ET) is a distinctive group of essential tremor (ET) in which tremor affects the neck, jaw, tongue, and/or...
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Association between esophageal motor disorders and pulmonary involvement in patients affected by systemic sclerosis: a retrospective study
Systemic sclerosis (SSc) is a rare autoimmune disease of the connective tissue that can affect multiple organs. The esophagus is the most affected...
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Cannabinoids as a Potential Alternative to Opioids in the Management of Various Pain Subtypes: Benefits, Limitations, and Risks
IntroductionPain is a global phenomenon encompassing many subtypes that include neuropathic, musculoskeletal, acute postoperative, cancer, and...
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The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway: A Bibliometric Analysis across 10 Years
Background and ObjectiveSince its initial report by James Parkinson in 1817, Parkinson’s disease (PD) has remained a central subject of research and...
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Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a randomized controlled trial
BackgroundImmersive virtual reality (VR)-based motor control training (VRT) is an innovative approach to improve motor function in patients with...
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Pre-operative cognitive burden as predictor of motor outcome following bilateral subthalamic nucleus deep brain stimulation in Parkinson’s disease
IntroductionThe interrelationship between neurocognitive impairments and motor functions was observed in patients with advanced Parkinson’s disease...
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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy
Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by a loss of the survival of motor neuron 1 ( SMN1 ) gene, resulting in a...
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Serum neurofilament light chain and postural instability/gait difficulty (PIGD) subtypes of Parkinson’s disease in the MARK-PD study
The PIGD (postural instability / gait difficulty) subtype of Parkinson´s disease (PD) is associated with faster cognitive and motor decline. So far,...
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Neurological update: non-motor symptoms in atypical parkinsonian syndromes
Among people with Parkinson’s disease (PD), non-motor symptoms (NMS) are a well-recognised cause of significant morbidity and poor quality of life....
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Clinical and genotypic analysis in determining dystonia non-motor phenotypic heterogeneity: a UK Biobank study
The spectrum of non-motor symptoms in dystonia remains unclear. Using UK Biobank data, we analysed clinical phenotypic and genetic information in the...
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Early recombinant human growth hormone treatment improves mental development and alleviates deterioration of motor function in infants and young children with Prader–Willi syndrome
BackgroundRecombinant human growth hormone (rhGH) therapy has shown to improve height and body composition in children with Prader–Willi syndrome...
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Infra-tentorial brain tumor subtypes in children and adults—surgical outcome in an ethnic population with a single regional tertiary center
BackgroundTo analyze clinically and radiologically the surgical outcome like residual disease, progression of disease, recurrence, disabilities,...
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The effect of hypocalcemia on motor symptoms of Parkinson’s disease
BackgroundThe disabling nature of Parkinson’s disease (PD) impairs functional mobility and worsens quality of life. Calcium imbalances are thought to...
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Sovateltide (ILR-1620) Improves Motor Function and Reduces Hyperalgesia in a Rat Model of Spinal Cord Injury
BackgroundSpinal cord injury (SCI) presents a major global health challenge, with rising incidence rates and substantial disability. Although...
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Dystonic motor and phonic tics in Tourette syndrome
BackgroundDystonic tics differ from clonic tics by their slower and more sustained nature. Dystonic tics are often present in patients with Tourette...
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Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes
Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor that is implicated in a variety of psychiatric disorders including...
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How effective is fine motor training in children with ADHD? A sco** review
BackgroundMotor deficiencies are observed in a large number of children with ADHD . Especially fine motor impairments can lead to academic...