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Implementing precision oncology for sarcoma patients: the CCCLMUmolecular tumor board experience
PurposeDue to poor outcomes and limited treatment options, patients with advanced bone and soft tissue sarcomas (BS/STS) may undergo comprehensive...
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Molecular tumour boards — current and future considerations for precision oncology
Over the past 15 years, rapid progress has been made in developmental therapeutics, especially regarding the use of matched targeted therapies...
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Endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling
Advances in next-generation sequencing have made comprehensive genomic profiling (CGP) using tumor tissue specimens and liquid biopsy using blood...
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Molecular diagnostics in odontogenic tumors
BackgroundOdontogenic tumors (OTs) are rare, with an estimated incidence rate of less than 0.5 cases per 100,000 per year. The causes of OTs remain...
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Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organization and function of these...
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Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics
Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors manifesting in infancy. They split into four molecular types....
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Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: which phenotype should drive classification?
BackgroundSalivary duct carcinoma with rhabdoid features (SDC-RF) is a recently-described salivary gland tumor that bears striking histologic...
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Genomic and TCR profiling data reveal the distinct molecular traits in epithelial ovarian cancer histotypes
Epithelial ovarian cancer (EOC) is classified into five major histotypes: high-grade serous (HGSOC), low-grade serous (LGSOC), clear cell (CCOC),...
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Comprehensive profiling of enhancer RNA in stage II/III colorectal cancer defines two prognostic subtypes with implications for immunotherapy
BackgroundRecently, enhancer RNAs (eRNAs) have garnered attention as pivotal biomarkers for the onset and progression of cancer. However, the...
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High-Grade Endometrial Cancer: Molecular Subtypes, Current Challenges, and Treatment Options
Although many recent advancements have been made in women’s health, perhaps one of the most neglected areas of research is the diagnosis and...
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Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets
Signet ring cell carcinoma (SRCC) is rare: about 10% of gastric cancer (GC) and 1% of colorectal cancer (CRC). SRCC is associated with poor...
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Relationship of Histopathologic Parameters and Gene Expression Profiling in Malignant Melanoma
BackgroundHistopathologic characteristics (HC) are a mainstay in melanoma prognosis; gene expression profiling (GEP) has emerged as a potential...
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Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling
BackgroundGliosarcoma (GS) refers to the presence of mesenchymal differentiation (as seen using light microscopy) in the setting of glioblastoma (GB,...
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Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling
Infection results when a pathogen produces host tissue damage and elicits an immune response. Critically ill patients experience immune activation...
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Real-world genomic profiling of acute myeloid leukemia and the impact of European LeukemiaNet risk stratification 2022 update
BackgroundAcute myeloid leukemia (AML) is a myeloid neoplasm associated with a high morbidity and mortality. The diagnosis, risk stratification and...
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Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling
In vitro models of pediatric brain tumors (pBT) are instrumental for better understanding the mechanisms contributing to oncogenesis and testing new...
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Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay
PurposeTo evaluate the Stratipath Breast tool for image-based risk profiling and compare it with an established prognostic multigene assay for risk...
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Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Genomic analyses have redefined the molecular subgrou** of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide...
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Precision Medicine for the Treatment of Colorectal Cancer: the Evolution and Status of Molecular Profiling and Biomarkers
Purpose of ReviewThe application of advanced genomic testing to develop tumor-specific molecular profiles is essential to facilitating precision...
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Prevalent landscape of tumor genomic alterations of luminal B1 breast cancers using a comprehensive genomic profiling assay in Taiwan
BackgroundThe human epidermal growth factor receptor 2 (HER2) negative luminal B1 subtype of breast cancer has been reported with a poorer outcome...
