Search
Search Results
-
Towards an understanding of psychedelic-induced neuroplasticity
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and...
-
Psilocybin Efficacy and Mechanisms of Action in Major Depressive Disorder: a Review
Purpose of the ReviewWe aim to provide an overview of the current state of knowledge about the efficacy of psilocybin in the treatment of depression,...
-
Psilocybin in Palliative Care: An Update
Purpose of ReviewThis review article summarizes clinically and socially relevant developments over the past five years in the therapeutic use of the...
-
Combining Isotopic Tracer Techniques to Increase Efficiency of Clinical Pharmacokinetic Trials in Oncology
With increasing numbers of drugs tested in oncology for smaller patient populations, fewer patients are available to answer important clinical...
-
Quantifying the Impact of Signal-to-background Ratios on Surgical Discrimination of Fluorescent Lesions
PurposeSurgical fluorescence guidance has gained popularity in various settings, e.g., minimally invasive robot-assisted laparoscopic surgery. In...
-
Dose-finding studies in drug development for rare genetic diseases
BackgroundThe small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One...
-
Fundamentals and developments in fluorescence-guided cancer surgery
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the past decade as a promising and effective method of...
-
Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients
PurposeAGM-130 is a cyclin-dependent kinase inhibitor that exhibits dose-dependent efficacy in xenograft mouse models. During preclinical...
-
Achieving net-zero in the dry eye disease care pathway
Climate change is a threat to human health and wellbeing across the world. In recent years, there has been a surge in awareness of this crisis,...
-
Pilot study of a novel nanobody 68 Ga-NODAGA-SNA006 for instant PET imaging of CD8+ T cells
PurposePositron emission tomography (PET) with specific diagnostic probes for quantifying CD8 + T cells has emerged as a powerful technique for...
-
In Vivo MRI Tracking of Tumor Vaccination and Antigen Presentation by Dendritic CellsCancer vaccination using tumor antigen-primed dendritic cells (DCs) was introduced in the clinic some 25 years ago, but the overall outcome has not...
-
Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users
Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on...
-
Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?
Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these...
-
The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review
Background and ObjectivesThe renewed interest in psychedelic research provides growing evidence of potentially unique effects on various aspects of...
-
Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Corona Virus Disease-19 (Covid-19): A structured summary of a study protocol for a randomised controlled trial
ObjectivesPrimary objective: Evaluation of the effect of the proton pump inhibitor (PPI) pantoprazole on the absorption of hydroxychloroquine (HCQ).
... -
Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism
BackgroundWe previously showed the practical and ethical feasibility of using [ 14 C]-microdosing for pharmacokinetic studies in children. We now...
-
Pharmakotherapie von Angsterkrankungen – leitliniengerechte Therapie und Neuentwicklungen
Besides cognitive behavioral therapy (CBT), psychopharmacotherapy belongs to the first-line treatment approaches for anxiety disorders according to...
-
Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy
PurposeAccurate identification of nodal status enables adequate neck irradiation for nasopharyngeal carcinoma (NPC). However, most conventional...
