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High interleukin-18 and low FOXP3 mRNAs in peripheral blood of women with severe systemic lupus erythematosus: a cross-sectional study
Gene expression analysis of peripheral blood cells may provide valuable information about the triggered molecular processes in systemic lupus...
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Relationship of FDG PET/CT imaging features with tumor immune microenvironment and prognosis in colorectal cancer: a retrospective study
BackgroundImaging features of colorectal cancers on 2-deoxy-2-[ 18 F]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT)...
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Role of IL33 in chronic inflammation and microvascular damage as a reflection of organ damage on a cohort of patients with acromegaly
AimAcromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact...
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A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation
Chronic unresolving inflammation is emerging as a key underlying pathological feature of many if not most diseases ranging from autoimmune conditions...
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Identification of the Minimal Disease Activity Domains Achieved Based on Different Treatments in Psoriatic Arthritis
IntroductionThe aim of this work is to characterize which Minimal Disease Activity (MDA) domains are mainly achieved, based on different treatments,...
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Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
Inflammation plays a major role in the development and progression of breast cancer(BC). Proliferation, invasion, angiogenesis, and metastasis are...
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Quercetin Supplement to Aspirin Attenuates Lipopolysaccharide-Induced Pre-eclampsia-Like Impairments in Rats Through the NLRP3 Inflammasome
Background and ObjectivesAspirin is a common drug for the treatment of pre-eclampsia. We aimed to explore whether quercetin as a supplement to...
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PD1 blockade alters cell-cycle distribution and affects 3′-deoxy-3′-[18F]fluorothymidine uptake in a mouse CT26 tumor model
ObjectiveWe previously reported that alterations of the tumor microenvironment (TME) by programmed death receptor-1 (PD1) blockade affected tumor...
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A high α1-antitrypsin/interleukin-10 ratio predicts bacterial pneumonia in adults with community-acquired pneumonia: a prospective cohort study
BackgroundCurrent microbiological tests fail to identify the causative microorganism in more than half of all pneumonia cases. We explored biomarkers...
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A randomized, double-blinded, placebo-controlled clinical trial of sterile filtered human amniotic fluid for treatment of COVID-19
ImportanceAcellular human amniotic fluid (hAF) is an antimicrobial and anti-inflammatory fluid that has been used to treat various pro-inflammatory...
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Familiäres Mittelmeerfieber – Rolle der Interleukin-1-Blockade in der Therapie
Familial Mediterranean fever (FMF) is the most common autoinflammatory disease and belongs to the monogenetic periodic fever syndromes. It results...
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Drug Survival of IL-17 and IL-23 Inhibitors for Psoriasis: A Systematic Review and Meta-Analysis
Background and ObjectiveThe most recently approved biologics for moderate-to-severe psoriasis are the interleukin (IL)-17 and IL-23 inhibitors. Drug...
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Effectiveness of Ixekizumab in Chinese Patients with Moderate-Severe Plaque Psoriasis with Special Area Involvement: Subanalysis of a Prospective, Multicenter, Observational Real-World Study
IntroductionIxekizumab, a monoclonal antibody against interleukin-17A, demonstrated effectiveness in the treatment of psoriasis in a Chinese...
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Study Design of a Phase 2/3 Randomized Controlled Trial of Dupilumab in Adults with Bullous Pemphigoid: LIBERTY-BP ADEPT
BackgroundBullous pemphigoid (BP) is a rare, autoimmune, blistering skin disease associated with high disease burden, profoundly decreased quality of...
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Hematologic and biochemical inflammatory markers increase with body mass and positively correlate in adolescents
BackgroundAtherosclerosis is a chronic inflammatory disease that has its origins in childhood. The goal of this study was to explore the...
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Clinical, metabolic, and immunological characterisation of adult Ugandan patients with new-onset diabetes and low vitamin D status
BackgroundLow vitamin D concentrations are associated with metabolic derangements, notably insulin resistance and pancreatic beta-cell dysfunction in...
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Artificial intelligence guided HRCT assessment predicts the severity of COVID-19 pneumonia based on clinical parameters
BackgroundThe purpose of the study was to compare the results of AI (artificial intelligence) analysis of the extent of pulmonary lesions on HRCT...
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Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers
ObjectiveWe aimed to assess patients with axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) for disease activity and serum markers...
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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia
In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identified promptly, could be fatal. It is the leading...
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Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial
IntroductionPsoriasis is a common skin disorder associated with physical and psychological burdens. Visible disfiguration can trigger a negative...
