Search
Search Results
-
Clonal evaluation of prostate cancer molecular heterogeneity in biopsy samples by dual immunohistochemistry and dual RNA in situ hybridization
Prostate cancer is frequently multifocal. Although there may be morphological variation, the genetic underpinnings of each tumor are not clearly...
-
Tissue Fixation Conditions for p16 Immunohistochemistry and Human Papillomavirus RNA In Situ Hybridization in Oropharyngeal Squamous Cell Carcinoma
Human papillomavirus (HPV) has become a critical prognostic biomarker in oropharyngeal squamous cell carcinoma (OPSCC). While retrospective studies...
-
Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus
Background/objectiveAcral and cutaneous melanomas are usually difficult to accurately diagnose in the early stage, owing to the similarity in...
-
Clinical significance of phenoty** and karyoty** of detecting circulating tumor cells in renal cell carcinoma using subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH)
Background and ObjectivesCirculating tumor cells (CTCs) as a noninvasive detection technology have become a research hotspot in the field of...
-
Primary Epithelioid Angiosarcoma of the Submandibular Gland—A Case Report with Histology-Cytology Correlation and Comprehensive Molecular Analysis
BackgroundAngiosarcoma is a sarcoma that occurs in a range of tissue types, and only rarely in the salivary glands, showing a predilection for the...
-
MYCN RNA levels determined by quantitative in situ hybridization is better than MYCN gene dosages in predicting the prognosis of neuroblastoma patients
The aim of this study was to investigate the prognostic role of MYCN RNA expression by quantitative RNA in situ hybridization and its association...
-
Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma with significant granuloma: case report and literature review
BackgroundEpstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+IFDCS) is a rare disease characterized by mild clinical...
-
Terminal microdeletion of chromosome 18 in a Malaysian boy characterized with few features of typical 18q- deletion syndrome: a case report
BackgroundThe 18q- deletion syndrome is a rare congenital chromosomal disorder caused by a partial deletion of the long arm of chromosome 18. The...
-
Handbook of Practical Immunohistochemistry Frequently Asked Questions
As in the second edition, the third edition of Handbook of Practical Immunohistochemistry – Frequently Asked Questionsis written in a question and...
-
Papillary renal neoplasm with reverse polarity has low frequency of alterations in chromosomes 7, 17, and Y
In papillary renal neoplasm with reverse polarity (PRNRP), the status of chromosomal copy number alterations, especially chromosomes 7/17 gain and...
-
Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
BackgroundThe pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing...
-
Accuracy of a reverse dot blot hybridization assay for simultaneous detection of the resistance of four anti-tuberculosis drugs in Mycobacterium tuberculosis isolated from China
BackgroundDrug resistant tuberculosis poses a great challenge for tuberculosis control worldwide. Timely determination of drug resistance and...
-
Recent advances in molecular profiling of bone and soft tissue tumors
The molecular characterization of soft tissue and bone tumors is a rapidly evolving field that has changed the perspective of how these tumors are...
-
A rare co-existence of histiocytic necrotizing lymphadenitis with metastatic papillary thyroid carcinoma and review of the literature
Histiocytic necrotizing lymphadenitis (HNL) is a benign, self-limiting disease that is rare clinically. The coexistence of HNL and tumor is rarer. We...
-
Plasmablastic lymphoma occurring in ulcerative colitis during treatment with immunosuppressive therapy
A 53-year-old man who had a history of ulcerative colitis (UC) for 2 years underwent colonoscopy as regular follow-up. The results showed an elevated...
-
Clinicopathological study of pseudomyogenic hemangioendothelioma
ObjectivesPseudomyogenic hemangioendothelioma (PHE) is a rare intermediate hemangioendothelioma. This article aims to study the clinicopathological...
-
The impact of 2018 ASCO-CAP HER2 testing guidelines on breast cancer HER2 results. An audit of 2132 consecutive cases evaluated by immunohistochemistry and in situ hybridization
The 2018 iteration of the ASCO-CAP HER2 testing guidelines proposes significant changes with an emphasis on the integration of concurrent...
-
Anaplastic large cell lymphoma presenting as a mass in the uterine cervix: a case report
T-cell lymphoma is an extremely rare form of malignancy in the female genital tract. Most of the reported cases of lymphoma are B-cell lymphomas. A...
-
Genomic technologies for detecting structural variations in hematologic malignancies
Genomic structural variations in myeloid, lymphoid, and plasma cell neoplasms can provide key diagnostic, prognostic, and therapeutic information...
-
Sperm chromosomal abnormalities in infertile men with failed intracytoplasmic sperm injection (ICSI)
BackgroundMale infertility is a major health problem with multi-factorial etiology. Intracytoplasmic sperm injection (ICSI) has revolutionized the...
