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Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer
Human leukocyte antigen class I (HLA I) molecules composed of alpha (heavy) chain, including HLA-A, -B, or -C encoded by HLA genes, and...
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Allogeneic Chimeric Antigen Receptor Therapy in Lymphoma
The therapeutic armamentarium has significantly expanded since the approval of various CD19-targeting chimeric antigen receptor T cell (CAR-T)...
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Proteomics analysis of lysine crotonylation and 2-hydroxyisobutyrylation reveals significant features of systemic lupus erythematosus
Introduction/objectivesTo seek significant features of systemic lupus erythematosus (SLE) by utilizing bioinformatics analysis.
Method ...
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Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer
About 85% of patients with colorectal cancer (CRC) have the non-microsatellite instability-high (non-MSI-H) subtype, and many cannot benefit from...
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Carcinogenesis and management of human papillomavirus-associated cervical cancer
Approximately 95% of cervical cancer are caused by human papillomavirus (HPV) infection. Although it is estimated that HPV-associated cervical cancer...
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Anti-GAD antibody-positive fulminant type 1 diabetes developed following SARS-CoV-2 vaccination
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been used worldwide since the 2020 coronavirus pandemic. However,...
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Engineering T-cells with chimeric antigen receptors to combat hematological cancers: an update on clinical trials
Chimeric antigen receptor (CAR) redirected T-cells has shown efficacy in the treatment of B-cell leukemia/lymphoma, however, high numbers of relapses...
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Introducing Molecular Chaperones into the Causality and Prospective Management of Autoimmune Hepatitis
Molecular chaperones influence the immunogenicity of peptides and the activation of effector T cells, and their pathogenic roles in autoimmune...
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PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin
This MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and highlights the importance of validating PDX models for the...
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Overexpression of SerpinB9 in non-seminomatous germ cell tumors
Serpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis...
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Genetic Engineering of Donor Pig for the First Human Cardiac Xenotransplantation: Combatting Rejection, Coagulopathy, Inflammation, and Excessive Growth
Purpose of ReviewThe first successful pig to human cardiac xenotransplantation in January 2022 represented a major step forward in the fields of...
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Building a human lung from pluripotent stem cells to model respiratory viral infections
To protect against the constant threat of inhaled pathogens, the lung is equipped with cellular defenders. In coordination with resident and...
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Visualizing γδ T cells by very late antigen-4-targeted positron emission tomography
Purposeγδ T cell–based immunotherapy has been rolled out as a promising treatment strategy for malignant tumors due to their potent anti-tumor...
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Risk factors and long-term outcomes for human herpesvirus 6 encephalitis in the early period after allogeneic stem cell transplantation
Human herpesvirus 6 (HHV6) encephalitis is a rare but life-threatening complication for patients undergoing allogeneic hematopoietic stem cell...
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Understanding Molecules that Mediate Leukocyte Extravasation
Purpose of ReviewGetting leukocytes to the site of inflammation is extremely important for maintaining homeostasis. Over time, leukocyte...
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Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric antigen receptors (CARs) re-direct NK cells toward tumor...
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Immune checkpoint inhibitor-related type 1 diabetes mellitus which develops long after treatment discontinuation: a case report and review of literature
Immune checkpoint inhibitor (ICI)-related type 1 diabetes is an immune-related adverse event (irAE), occurring in slightly less than 1% of patients...
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Associations between human leukocyte antigen polymorphisms and hypersensitivity to antiretroviral therapy in patients with human immunodeficiency virus: a meta-analysis
BackgroundHuman leukocyte antigen (HLA) alleles are implicated in drug-induced hypersensitivity, including by nevirapine and abacavir. The purpose of...
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The potential pathogenic role of gut microbiota in rheumatic diseases: a human-centred narrative review
A growing amount of evidence suggests that gut microbiota plays an important role in human health, including a possible role in the pathogenesis of...
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Mechanism of action of DSP-7888 (adegramotide/nelatimotide) Emulsion, a peptide-based therapeutic cancer vaccine with the potential to turn up the heat on non-immunoreactive tumors
BackgroundWilms’ tumor 1 (WT1) is highly expressed in various solid tumors and hematologic malignancies. DSP-7888 (adegramotide/nelatimotide)...
