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1. Macrophage, the potential key mediator in CAR-T related CRS

   Chimeric antigen receptor (CAR) T cell therapy is a new frontier in cancer therapy. The toxicity of cytokine release syndrome (CRS) has become one of...

   Zhaonian Hao, Ruyuan Li, ... Zhenya Hong in Experimental Hematology & Oncology

   Article Open access 10 July 2020
   

2. DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

   Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil...

   Jun Chen, Tao Wang, ... Fuqiang Wen in Signal Transduction and Targeted Therapy

   Article Open access 17 June 2024
   

3. The M1/M2 spectrum and plasticity of malignant pleural effusion-macrophage in advanced lung cancer

   Background

   Malignant pleural effusion (MPE)-macrophage (Mφ) of lung cancer patients within unique M1/M2 spectrum showed plasticity in M1–M2...

   Ming-Fang Wu, Chih-An Lin, ... Huei-Wen Chen in Cancer Immunology, Immunotherapy

   Article Open access 11 November 2020
   

4. Enhancing the immune effect of oHSV-1 therapy through TLR3 signaling in uveal melanoma

   Purpose

   Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, with patients having a low overall survival rate....

   Sisi Liu, Mingxin Li, ... Fusheng Liu in Journal of Cancer Research and Clinical Oncology

   Article 28 August 2022
   

5. CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production

   Background

   Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of...

   Rajula Gaur, Kofi A. Mensah, ... Francisco Ramírez-Valle in Arthritis Research & Therapy

   Article Open access 18 August 2022
   

6. Inflammation in Brain-Dead Donor Organs and Therapeutic Approaches to It

   Purpose of Review

   The increasing number of patients on the waiting list for organ transplantation and organ shortage require the improvement of organ...

   Sara Assadiasl, Ahmadreza Sadeghi, ... Mohammad Hossein Nicknam in Current Transplantation Reports

   Article 16 March 2024

7. Immunology Updates in Recurrent Implantation Failure in In Vitro Fertilization

   Purpose of Review

   To summarize standards and recent advances in the understanding of immunology in recurrent implantation failure in IVF.

   ...

   Catherine Boniface, Navid Esfandiari in Current Obstetrics and Gynecology Reports

   Article 03 February 2024

8. Successful wound healing by autologous peripheral blood mononuclear cell therapy in a diabetic patient on hemodialysis with no-option critical limb ischemia: a case report

   Peripheral artery disease is a common condition in patients on chronic dialysis treatment, end-stage kidney failure itself being a risk factor. The...

   Martina Capone, Raffaele Trulli, ... Mario Bonomini in Journal of Nephrology

   Article 30 January 2024
   

9. The pleiotropic mode and molecular mechanism of macrophages in promoting tumor progression and metastasis

   Macrophages are the most abundant immune cells in primary and metastatic tumor tissues. Studies have shown that macrophages mainly exhibit a...

   **ngxing Zhang, Wenxiu Bai, ... Panfeng Shang in Clinical and Translational Oncology

   Article 07 September 2022
   

10. Targeted immunomodulation: a primer for intensivists

    Malou Janssen, Henrik Endeman, Lieuwe D. J. Bos in Intensive Care Medicine

    Article Open access 03 March 2023
    

11. Myeloid-derived suppressor cells in cancer and cancer therapy

    Anticancer agents continue to dominate the list of newly approved drugs, approximately half of which are immunotherapies. This trend illustrates the...

    Samantha A. Lasser, Feyza G. Ozbay Kurt, ... Viktor Umansky in Nature Reviews Clinical Oncology

    Article 08 January 2024
    

12. Spinal cord injury: molecular mechanisms and therapeutic interventions

    Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex...

    **ao Hu, Wei Xu, ... Liming Cheng in Signal Transduction and Targeted Therapy

    Article Open access 26 June 2023
    

13. The Role of Bacterial Extracellular Membrane Nanovesicles in Atherosclerosis: Unraveling a Potential Trigger

    Purpose of Review

    In this review, we explore the intriguing and evolving connections between bacterial extracellular membrane nanovesicles (BEMNs) and...

    Konstantin A. Lusta, Volha I. Summerhill, ... Alexander N. Orekhov in Current Atherosclerosis Reports

    Article 28 May 2024
    

14. Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments

    Histidine decarboxylase (HDC), a histamine synthase, is expressed in various hematopoietic cells and is induced by hematopoietic cytokines such as...

    Hirotada Otsuka, Yasuo Endo, ... Satoshi Soeta in International Journal of Hematology

    Article 04 January 2021
    

15. Exploring the potential of combining IL-2-activated NK cells with an anti-PDL1 monoclonal antibody to target multiple myeloma-associated macrophages

    Multiple myeloma (MM) is an incurable disease, characterized by malignant plasma cells in the bone marrow. MM growth is largely dependent on the...

    Femke A. I. Ehlers, Niken M. Mahaweni, ... Lotte Wieten in Cancer Immunology, Immunotherapy

    Article Open access 19 January 2023
    

16. Towards personalized medicine: a sco** review of immunotherapy in sepsis

    Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few proven therapies...

    Marleen A. Slim, Niels van Mourik, ... Lonneke A. van Vught in Critical Care

    Article Open access 28 May 2024
    

17. Cytokine dysregulation persists in childhood post Neonatal Encephalopathy

    Background

    Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to...

    Zunera Zareen, Tammy Strickland, ... Eleanor J. Molloy in BMC Neurology

    Article Open access 30 March 2020
    

18. New Biomarkers in Anaphylaxis (Beyond Tryptase)

    Purpose of Review

    The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying...

    P. Galvan-Blasco, J. Gil-Serrano, A. Sala-Cunill in Current Treatment Options in Allergy

    Article 28 November 2022
    

19. Serum cytokines and bone metabolic markers in patients with rheumatoid arthritis treated with biological disease modifying anti-rheumatic drugs

    Introduction

    /objectives

    Several biological disease-modifying anti-rheumatic drugs (bDMARDs) have been widely used for the management of rheumatoid...

    Hiroya Tamai, Naoshi Nishina, ... Yuko Kaneko in Clinical Rheumatology

    Article 26 September 2022
    

20. Functionalized chitosan-G-poly caprolactone vaccine delivery system fabricated to display antigen–antibody immune complexes of Mycobacterium tuberculosis elicits immune response in Ex-vivo model

    Background

    Vaccine development against tuberculosis remains a global health imperative, necessitating robust immunogenicity and safety profiles....

    Sam Ebenezer Rajadas, Vignesh Sounderrajan, ... Shakila Harshavardhan in Beni-Suef University Journal of Basic and Applied Sciences

    Article Open access 17 June 2024