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The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelium is a stratified epithelium composed of basal cells, one or more layers of intermediate cells, and an upper layer of differentiated...
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Gene therapy for liver diseases — progress and challenges
Gene therapy is poised to revolutionize modern medicine, with seemingly unlimited potential for treating and curing genetic disorders. For otherwise...
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Comprehensive analysis of autophagy-related gene expression profiles identified five gene biomarkers associated with immune infiltration and advanced plaques in carotid atherosclerosis
BackgroundAutophagy plays an important role in the progression of carotid atherosclerosis (CAS). This study aimed to identify hub autophagy-related...
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Methylation of promoter region of BRCA1 gene versus pathogenic variants of gene: risk factor or clinical marker of breast cancer
BackgroundIn this study, we compared the contribution of pathogenic variants of the BRCA1/2 genes (5382insC, 185delAG, 6174delT, 4153delA, T300G)...
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Relationship between BDNF gene polymorphisms and alcohol-related liver cirrhosis
Background and aimBrain-derived neurotrophic factor (BDNF) functions not only in the brain but also in peripheral tissues such as the liver. Genetic...
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Translocations and Gene Fusions in Sinonasal Malignancies
Purpose of ReviewDuring the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of...
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Identification of the potential association between SARS-CoV-2 infection and acute kidney injury based on the shared gene signatures and regulatory network
BackgroundThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is identified as the cause of coronavirus disease 2019...
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Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China
ObjectivesTo explore the prevalence and associated factors of obesity in Tibetan adults in Qinghai, China, and to determine the association between...
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Liposomal delivery of gene therapy for ovarian cancer: a systematic review
ObjectiveTo systematically identify and narratively synthesize the evidence surrounding liposomal delivery of gene therapy and the outcome for...
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Radiation-induced changes in gene expression in rectal cancer specimens
PurposeThe standard-of-care for locally advanced rectal cancer is radiotherapy-based neoadjuvant therapy followed by surgical resection. This article...
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miR-17-92a-1 cluster host gene: a key regulator in colorectal cancer development and progression
Colorectal cancer (CRC), recognized among the five most prevalent malignancies and most deadly cancers, manifests multifactorial influences stemming...
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Addressing Gene Modified Technology for Emerging Risks Through Regional Networks
Purpose of ReviewGene modified technology presents solutions across several disciplines including environment, medicine, agriculture, and industry....
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Association of ABCA1 gene with Coronary Artery Disease (CAD): an overview
BackgroundThis review is a summarized study on CAD, CVD, atherosclerosis, and its association with the ABCA1 gene. Only 13 clinical as well as...
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Development and clinical validation of a seven-gene signature based on tumor stem cell-related genes to predict ovarian cancer prognosis
ObjectiveTumors are highly heterogeneous, and within their parenchyma, a small population of tumor-stem cells possessing differentiation potential,...
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SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients
Background and purposePrimary hypothyroidism due to abnormality in the thyroid gland is the most common endocrine disease The recommended starting...
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Cell-cycle dependent nuclear gene delivery enhances the effects of E-cadherin against tumor invasion and metastasis
Gene delivery is the process by which foreign DNA is transferred to host cells, released from intracellular vesicles, and transported to the nuclei...
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An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
BackgroundAsthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develo** drugs that...
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Differential Gene Regulation of the Human Blastocyst Trophectoderm and Inner Cell Mass by Progesterone
Knowledge of action of progesterone (P4) on the human preimplantation embryo is lacking. The objective of this study was to determine expression of a...
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Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K/AKT signaling
BackgroundMicroRNAs are a type of non-coding single-stranded RNA, which is involved in the regulation of ovary insulin resistance (IR). This study...
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Partial GCK gene deletion mutations causing maturity-onset diabetes of the young
AimsMaturity-onset diabetes of the young (MODY) is an autosomal dominant monogenic form of diabetes, and glucokinase-maturity-onset diabetes of the...
