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Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study
BackgroundLow birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages....
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miR-17-92a-1 cluster host gene: a key regulator in colorectal cancer development and progression
Colorectal cancer (CRC), recognized among the five most prevalent malignancies and most deadly cancers, manifests multifactorial influences stemming...
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Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study
BackgroundThe majority of congenital heart diseases (CHDs) are thought to result from the interactions of genetics and the environment factors. This...
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Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study
BackgroundAutism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder that can significantly impact an individual’s ability to socially...
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Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits and repetitive...
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Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene–gene interactions
Kidney stone disease (KSD) represents an urgent medical problem because of increasing its prevalence. Several functional polymorphisms in genes...
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Autophagy-related gene model as a novel risk factor for schizophrenia
Autophagy, a cellular process where cells degrade and recycle their own components, has garnered attention for its potential role in psychiatric...
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Prevalence of bronchial asthma and correlation between the chemokine receptor 3 gene polymorphism and clinical asthma phenotypes among Egyptian asthmatic children
BackgroundAsthma is a chronic inflammatory airway disease characterized by episodic reversible airway obstruction that variably presents with cough,...
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Microbial modulation via cross-fostering prevents the effects of pervasive environmental stressors on microglia and social behavior, but not the dopamine system
Environmental toxicant exposure, including air pollution, is increasing worldwide. However, toxicant exposures are not equitably distributed. Rather,...
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Interaction between genetics and the adherence to the Mediterranean diet: the risk for age-related macular degeneration. Coimbra Eye Study Report 8
BackgroundAge-related macular degeneration (AMD) is a multifactorial degenerative disease of the macula. Different factors, environmental, genetic...
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The interaction between CRY1 Polymorphism and Alternative Healthy Eating Index (AHEI) on cardiovascular risk factors in overweight women and women with obesity: a cross-sectional study
BackgroundAccording to some studies, diet can be interaction with CRY1 polymorphism and may be related to obesity and the risk of cardiovascular...
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Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials
BackgroundBoth genetic background and diet are important determinants of cardiovascular diseases (CVD). Understanding gene-diet interactions could...
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Genetic and environmental mouse models of autism reproduce the spectrum of the disease
Genetic and environmental factors increase autism spectrum disorder (ASD) incidence, and this has led to the generation of corresponding animal...
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Gene Regulatory Networks in Coronary Artery Disease
Purpose of ReviewCoronary artery disease is a complex disorder and the leading cause of mortality worldwide. As technologies for the generation of...
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Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes...
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Recurrent urinary tract infection genetic risk: a systematic review and gene network analysis
Introduction and hypothesisThe development of recurrent urinary tract infections (rUTIs) is not completely understood. This review is aimed at...
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Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction
BackgroundThe epididymis is crucial for post-testicular sperm development which is termed sperm maturation. During this process, fertilizing ability...
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Association of BMAL1 clock gene polymorphisms with fasting glucose in children
BackgroundThe brain and muscle Arnt-like protein-1 ( BMAL1 ) gene is an important circadian clock gene and previous studies have found that certain...
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Association of leptin–melanocortin gene polymorphisms with the risk of obesity in northwest Indian population
BackgroundObesity, a multifaceted endocrine issue, is adversely affecting all age groups and is posing a significant public health challenge. The...
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Decoding the interaction between miR-19a and CBX7 focusing on the implications for tumor suppression in cancer therapy
Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth, genetic alterations, and disruption of normal cellular...
