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The putative pleiotropic functions of meprin β in gastric cancer
BackgroundThe gastric microbiome and inflammation play a key role in gastric cancer (GC) by regulating the immune response in a complex manner and by...
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Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori–naïve patients
Sporadic foveolar-type gastric adenoma (FGA) has been described as an extremely rare polyp that is whitish and flatly elevated. However, we recently...
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Meta-analysis of mucosal microbiota reveals universal microbial signatures and dysbiosis in gastric carcinogenesis
The consistency of the associations between gastric mucosal microbiome and gastric cancer across studies remained unexamined. We aimed to identify...
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Exploration of gastric carcinogenesis from the relationship between bile acids and intestinal metaplasia and intragastric microorganisms (H. pylori and non-H. pylori)
Gastric cancer (GC) is a prevalent form of cancer, with Helicobacter pylori ( H . pylori ) infection being the most common risk factor. Recent studies...
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The role of polyamines in gastric cancer
Advancements in our understanding of polyamine molecular and cellular functions have led to increased interest in targeting polyamine metabolism for...
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CDKN2A somatic copy number amplification in normal tissues surrounding gastric carcinoma reduces cancer metastasis risk in droplet digital PCR analysis
BackgroundThe CDKN2A gene is frequently affected by somatic copy number variations (SCNVs, including deletions and amplifications [SCNdel and...
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CD10 and Das1: a biomarker study using immunohistochemistry to subtype gastric intestinal metaplasia
BackgroundIntestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into...
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Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity
Single-cell transcriptomic profiles analysis has proposed new insights for understanding the behavior of human gastric cancer (GC). GC offers a...
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The investigation of volatile organic compounds in diagnosing (early) esophageal squamous cell carcinoma and gastric adenocarcinoma
PurposeThe diagnosis of upper gastrointestinal cancer (UGIC) and early UGIC is currently based on endoscopy and histopathology. In this study, we...
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Diagnosis and Management of Epithelial Precancerous Conditions and Lesions in the Stomach
Purpose of reviewChronic atrophic gastritis and intestinal metaplasia are associated with higher gastric cancer risk and guidelines recommend...
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Confocal endomicroscopy diagnostic criteria for early signet-ring cell carcinoma in hereditary diffuse gastric cancer
BackgroundRecognition of early signet-ring cell carcinoma (SRCC) in patients with hereditary diffuse gastric cancer (HDGC) undergoing endoscopic...
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Current molecular biomarkers evaluation in gastric/gastroesophageal junction adenocarcinoma: pathologist does matter
The comprehensive molecular characterization of gastric and gastroesophageal junction adenocarcinomas has led to the improvement of targeted and more...
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Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms
AimGenetic variants contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study is to evaluate the association of 45...
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Multiple intraductal papillary neoplasms of bile duct diagnosed based on endoscopic ultrasonography and peroral cholangioscopy findings
A man in his 30s was referred to our department for evaluation of bile duct stricture and removal of an intrahepatic bile duct stone. Five years...
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Helicobacter pylori and gastric cancer: a lysosomal protease perspective
The intimate involvement of pathogens with the heightened risk for develo** certain cancers is an area of research that has captured a great deal...
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Association between metabolic syndrome and gastric cancer risk: results from the Health Examinees Study
BackgroundPrevious studies suggested that metabolic syndrome (MetS) might create a pro-cancer environment and increase cancer incidence. However,...
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Development, validation, and evaluation of a risk assessment tool for personalized screening of gastric cancer in Chinese populations
BackgroundEffective risk prediction models are lacking for personalized endoscopic screening of gastric cancer (GC). We aimed to develop, validate,...
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Protective effects of all-trans retinoic acid against gastric premalignant lesions by repressing exosomal LncHOXA10–pyruvate carboxylase axis
PurposeLong noncoding RNAs (LncRNAs) play a pivotal role in gastric tumorigenesis, while exosomes facilitate the LncRNAs transferring to recipient...
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A case of ectopic pancreas of the stomach accompanied by intraductal papillary mucinous neoplasm with GNAS mutation
BackgroundEctopic pancreas is basically a benign disease and is not always necessary to be removed. However, all types of neoplasms occurring in the...
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CACA guidelines for holistic integrative management of gastric cancer
According to statistics, the rates of incidence and death of gastric cancer in China have risen to the fourth worldwide, resulting in huge social...
