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Vitamin A deficiency after prolonged intake of an unbalanced diet in a Japanese hemodialysis patient
BackgroundIn industrialized countries, vitamin A deficiency (VAD) is extremely rare, except association with bariatric surgeries and hepatobiliary...
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Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models
BackgroundCrosstalk between pericytes and endothelial cells is critical for ocular neovascularization. Endothelial cells secrete platelet-derived...
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Oscillatory potentials in patients with birdshot chorioretinopathy
PurposeThe electroretinogram (ERG) has proven to be useful in the evaluation and monitoring of patients with posterior uveitis. ERG oscillatory...
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Retinal function determined by flicker ERGs before and soon after intravitreal injection of anti-VEGF agents
BackgroundTo evaluate the retinal function before and soon after an intravitreal injection of an anti-vascular endothelial growth factor (anti-VEGF)...
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SPOAN syndrome: a novel mutation and new ocular findings; a case report
BackgroundTo report a novel mutation and new clinical findings in a case with SPOAN syndrome (spastic paraplegia, optic atrophy, neuropathy).
...
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Phenotypic variability in PRPH2 as demonstrated by a family with incomplete penetrance of autosomal dominant cone-rod dystrophy
IntroductionMutations in the peripherin-2 gene ( PRPH2 ) are a common cause of inherited retinal dystrophies well known for their phenotypic...
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Siderotic glaucoma without detectable intraocular foreign body in a pseudophakic eye: a case report
BackgroundOcular siderosis is induced by a retained intraocular foreign body (IOFB) containing iron and can present as siderotic glaucoma. We report...
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Evolution of macular hole in enhanced S-cone syndrome
PurposeTo describe the stages of development and natural course of a full-thickness macular hole (FTMH) in a patient with enhanced S-cone syndrome...
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Myopia-26, the female-limited form of early-onset high myopia, occurring in a European family
BackgroundFemale-limited early-onset high myopia, also called Myopia-26 is a rare monogenic disorder characterized by severe short sightedness...
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Two cases of unilateral cone–rod dysfunction presenting in adult females
PurposeTo describe cases of unilateral cone–rod dysfunction presenting in two middle-aged females.
MethodsThis case series highlights two...
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Preclinical assessment of intravitreal ramucirumab: in vitro and in vivo safety profile
BackgroundAnti-angiogenic drugs remain the mainstay therapy for several vascular retinal pathologies. The repurposing of approved anti-angiogenic...
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Analysis of retinal structure and function in cone dystrophy with supernormal rod response
PurposeTo report the clinical and electrophysiological features of cone dystrophy with supernormal rod response (CDSRR).
MethodsRetrospective cohort...
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Hand-held, dilation-free, electroretinography in children under 3 years of age treated with vigabatrin
PurposeThe anti-epileptic drug vigabatrin is associated with reduction in light-adapted 30-Hz flicker electroretinogram (ERG) amplitude....
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Intravitreal metoprolol for circumscribed choroidal hemangiomas: a phase I clinical trial
BackgroundChoroidal hemangioma is a visual threatening condition for which treatments is neither uniform nor widely available . New management...
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S-cone contribution to oscillatory potentials in patients with blue cone monochromacy
PurposeThe aim of this exploratory study is to investigate the role of S-cones in oscillatory potentials (OPs) generation by individuals with...
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Electroretinographic Assessment in Joubert Syndrome: A Suggested Objective Method to Evaluate the Effectiveness of Future Targeted Treatment
IntroductionJoubert syndrome (JS) is an autosomal recessive disorder characterized by a congenital malformation of the mid-hindbrain and a large...
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Long-term full-field and multifocal electroretinographic changes after treatment with ranibizumab in patients with diabetic macular edema
PurposeTo investigate changes in macular and panretinal neuroretinal functions by electroretinographic examinations in eyes with diabetic macular...
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Long-term follow-up of retinal morphology and physiology after 2000 mg sildenafil overdose as a means of attempted suicide: a case report
BackgroundFew case reports have described sildenafil overdose, particularly ingestion of > 1000 mg, and overdose-induced changes in visual function...
