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Showing 61-80 of 8,098 results

  1. Aberrant peripheral blood CD4+ CD25+ FOXP3+ regulatory T cells/T helper-17 number is associated with the outcome of patients with lymphoma

    Little is known about the clinical significance of the peripheral blood CD4 + CD25 + FOXP3 + regulatory T cells (Tregs) and T helper-17 (Th17) cells in...

    Mehdi Dehghani, Mehdi Kalani, ... Nargess Arandi in Cancer Immunology, Immunotherapy
    Article 08 May 2020

  2. GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancer

    Background

    Local tumor microenvironment (TME) plays a crucial role in immunotherapy for breast cancer (BC). Whereas, the molecular mechanism...

    **aofeng li, Yiwen Chen, ... Wei Chen in Discover Oncology
    Article Open access 27 July 2023

  3. A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

    This study sought to identify molecular subtypes of breast cancer (BC) and develop a breast cancer stem cells (BCSCs)-related gene risk score for...

    Haihong Hu, Mingxiang Zou, ... Taolan Zhang in npj Precision Oncology
    Article Open access 08 December 2023

  4. Metabolites of Trichoderma harzianum re-balance T-reg/Th-17 cytokine axis in epileptic rats

    Background

    Recurrent seizure is synchronous neuronal network hyperexcitation. Even though many anti-epileptic drugs (AEDs) are available, but have...

    Mohamed A. Alblihed in Beni-Suef University Journal of Basic and Applied Sciences
    Article Open access 04 December 2023

  5. T helper cell polarity determines salt sensitivity and hypertension development

    High-salt intake is known to induce pathogenic T helper (Th) 17 cells and hypertension, but contrary to what is known, causes hypertension only in...

    Jee Young Kim, Soyung Lee, ... Inkyeom Kim in Hypertension Research
    Article 18 July 2023

  7. Heterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy

    Objective

    AT-rich interaction domain 1A (ARID1A) mutant tumors show active anti-tumor immune response, which is the potential indication of...

    **n Guan, Luying Cui, ... Chao Liu in Discover Oncology
    Article Open access 31 March 2024

  8. High interleukin-18 and low FOXP3 mRNAs in peripheral blood of women with severe systemic lupus erythematosus: a cross-sectional study

    Gene expression analysis of peripheral blood cells may provide valuable information about the triggered molecular processes in systemic lupus...

    Lyuba D. Miteva, Irena M. Manolova, ... Spaska A. Stanilova in Rheumatology International
    Article 09 March 2020

  9. Prognostic value and clinicopathological roles of the tumor immune microenvironment in salivary duct carcinoma

    Salivary duct carcinoma (SDC) is an aggressive type of salivary gland carcinoma. Recently, immunotherapies targeting immune checkpoints, including...

    Hideaki Hirai, Masato Nakaguro, ... Toshitaka Nagao in Virchows Archiv
    Article 19 July 2023

  10. Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism

    Background

    Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune...

    Chong Shen, Dandan Zong, ... Ruoyun Ouyang in Sleep and Breathing
    Article 03 February 2024

  11. Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ

    Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the CNS characterized by the production of disease-specific autoantibodies...

    Akihiro Nakajima, Fumihiro Yanagimura, ... Izumi Kawachi in Acta Neuropathologica
    Article 24 April 2024

  12. Quantitative analysis of Tr1 lymphocytes in patients with type 2 diabetes mellitus

    Background

    Type 2 diabetes mellitus (T2DM) is usually accompanied by a low-grade inflammatory phenomenon, which participates in the pathogenesis of...

    C. Knott-Torcal, N. S. de la Blanca, ... M. Marazuela in Journal of Endocrinological Investigation
    Article Open access 06 January 2024

  13. Clinical significance of antinuclear antibody as prognostic marker for first-line pembrolizumab in advanced non-small cell lung cancer

    Background

    The relationship between antinuclear antibody (ANA) and the efficacy of programmed death-1 (PD-1) blockade remains controversial. Here, we...

    Atsuto Mouri, Kyoichi Kaira, ... Hiroshi Kagamu in International Journal of Clinical Oncology
    Article 31 December 2023

  14. PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

    The programmed cell death 1 protein (PD-1)/programmed cell death ligand 1 (PD-L1) axis plays a crucial role in tumor immunosuppression, while the...

    Kento Kawasaki, Kazuhiro Noma, ... Toshiyoshi Fujiwara in Cancer Immunology, Immunotherapy
    Article Open access 05 September 2023

  15. Neoadjuvant Chemoimmunotherapy Increases Tumor Immune Lymphocytes Infiltration in Resectable Non-small Cell Lung Cancer

    Background

    Neoadjuvant chemoimmunotherapy treatment (NCIT) has achieved great success for non-small cell lung cancer (NSCLC); however, the intrinsic...

    Tianxiang Chen, Zhengqi Cao, ... Ziming Li in Annals of Surgical Oncology
    Article 16 August 2023

  16. Pentoxifylline changes the balance of immune cell population in breast tumor-infiltrating lymphocytes

    Immunotherapy utilizing tumor-infiltrating lymphocytes (TILs) is a promising approach for cancer treatment. Pentoxifylline (PTXF), a xanthine...

    Mohammad Hossein Kazemi, Mahdieh Shokrollahi Barough, ... Reza Falak in Medical Oncology
    Article Open access 06 May 2023

  17. IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer

    Background

    The prognosis for patients with colorectal cancer (CRC) is determined by tumor characteristics as well as the host immune response. This...

    Tsunenori Yamamoto, Ryouichi Tsunedomi, ... Hiroaki Nagano in Annals of Surgical Oncology
    Article 24 May 2023

  18. Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation

    Background

    Cepharanthin ® alone or in combination with glucocorticoid (GC) has been used to treat chronic immune thrombocytopenia (ITP) since the...

    Wencheng Xu, Shuhe Chen, ... Toshihiko Hirano in BMC Complementary Medicine and Therapies
    Article Open access 11 May 2024

  19. Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma

    Background & aims

    Combination immunotherapy refers to the use of immune checkpoint inhibitors (ICI) and molecular-targeted agents (MTA), which have...

    Hiroyuki Suzuki, Hideki Iwamoto, ... Takumi Kawaguchi in Hepatology International
    Article Open access 21 October 2023

  20. Intratumoral T cell depletion following neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer is associated with poor clinical outcome

    Background

    Whereas neoadjuvant cisplatin-based chemotherapy (NAC) followed by a radical cystectomy remains the standard treatment for patients with...

    Sandra van Wilpe, Shabaz Sultan, ... Niven Mehra in Cancer Immunology, Immunotherapy
    Article Open access 30 June 2022
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