Search
Search Results
-
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Tourette Syndrome (TS) is a neuropsychiatric disorder thought to involve a reduction of basal ganglia (BG) interneurons and malfunctioning of the BG...
-
Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also causes cognitive impairment, neurotoxicity and neurodevelopmental...
-
Vascular endothelial cell development and diversity
Vascular endothelial cells form the inner layer of blood vessels where they have a key role in the development and maintenance of the functional...
-
Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons
Congenital myasthenic syndromes (CMS) are predominantly characterized by muscle weakness and fatigability and can be caused by a variety of mutations...
-
Endogenous mutant Huntingtin alters the corticogenesis via lowering Golgi recruiting ARF1 in cortical organoid
Pathogenic mutant huntingtin (mHTT) infiltrates the adult Huntington’s disease (HD) brain and impairs fetal corticogenesis. However, most HD animal...
-
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36 children in the United States. While neurons have been the...
-
Mouse oocyte vitrification with and without dimethyl sulfoxide: influence on cryo-survival, development, and maternal imprinted gene expression
PurposeOocytes and embryos can be vitrified with and without dimethyl sulfoxide (DMSO). Objectives were to compare no vitrification (No-Vitr),...
-
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer’s disease (AD) is of great importance for the rational...
-
SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration
GEMIN5 is essential for core assembly of small nuclear Ribonucleoproteins (snRNPs), the building blocks of spliceosome formation. Loss-of-function...
-
Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from...
-
The role of organoids in cancer research
Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo....
-
An Embryonic and Induced Pluripotent Stem Cell Model for Ovarian Granulosa Cell Development and Steroidogenesis
Embryoid bodies (EBs) can serve as a system for evaluating pluripotency, cellular differentiation, and tissue morphogenesis. In this study, we use...
-
Advancing preclinical models of psychiatric disorders with human brain organoid cultures
Psychiatric disorders are often distinguished from neurological disorders in that the former do not have characteristic lesions or findings from...
-
Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation
During implantation, a symphony of interaction between the trophoblast originated from the trophectoderm of the implanting blastocyst and the...
-
Benchmarking brain organoid recapitulation of fetal corticogenesis
Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in...
-
Selected Topics in the Pathology of the Thyroid and Parathyroid Glands in Children and Adolescents
The goals of this chapter in kee** with the overall general themes of this special edition will be (1) to highlight aspects of development of the...
-
Germline stem cells in human
The germline cells are essential for the propagation of human beings, thus essential for the survival of mankind. The germline stem cells, as a...
-
Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder caused by genetic or environmental perturbations during early development....
-
Modeling Congenital Heart Disease Using Pluripotent Stem Cells
AbstractCongenital heart disease (CHD) represents a major class of birth defects worldwide and is associated with cardiac malformations that often...
-
TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling
BackgroundTuberous sclerosis complex (TSC) is a neurodevelopmental disorder with frequent occurrence of epilepsy, autism spectrum disorder (ASD),...
