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Basic Epigenetic Mechanisms of Aging

Abstract

The process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and...

I. D. Strazhesko, A. P. Yesakova, ... O. N. Tkacheva in Advances in Gerontology

Article 01 June 2023

Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung’s disease

Background

Hirschsprung’s disease (HSCR) is a common birth defect caused by dysplasia of neural crest cells in the gut. Long noncoding RNAs (lncRNAs)...

Long Li, **ao Li, ... Rongde Wu in Pediatric Surgery International

Article 14 July 2022

Mitochondrial epigenetic modifications and nuclear-mitochondrial communication: A new dimension towards understanding and attenuating the pathogenesis in women with PCOS

Mitochondrial DNA (mtDNA) epigenetic modifications have recently gained attention in a plethora of complex diseases, including polycystic ovary...

Pallavi Shukla, Girish C. Melkani in Reviews in Endocrine and Metabolic Disorders

Article 27 January 2023

Role of epigenetics in OSCC: an understanding above genetics

Oral cavity cancer is categorized under head and neck cancer that frequently develops from squamous cells hence also known as oral squamous cell...

Priyanka P. Vatsa, Yogita **dal, ... Amit Mandoli in Medical Oncology

Article 20 March 2023

CRISPR-Cas9-mediated gene therapy in lung cancer

As the largest cause of cancer-related deaths worldwide, pulmonary cancer is the most common form of the disease. Several genetic, epigenetic, and...

Hossein Kazemizadeh, Alireza Kashefizadeh in Clinical and Translational Oncology

Article 10 December 2022

Correction: New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

Mengyuan Dai, Miao Liu, ... Hua You in Experimental Hematology & Oncology

Article Open access 19 December 2022

Comprehensive gene expression analysis of histone deacetylases and the transcription factor Nrf2 in the progression of diabetic nephropathy

Background

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial transcription factor in maintaining cellular homeostasis. The regulation of...

Kannan Harithpriya, Udyama Juttada, ... Kunka Mohanram Ramkumar in International Journal of Diabetes in Develo** Countries

Article 21 June 2024

Mitteilungen der DGIM

in Die Innere Medizin

Article 21 June 2023

Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

Drug resistance is a major problem limiting the efficacy of chemotherapy in cancer treatment, and the hypoxia-induced stabilization of HIF-1α plays a...

Tzu-Tang Wei, Yi-Ting Lin, ... Ching-Chow Chen in Oncogene

Article 02 September 2019

The Role of Epigenetics in the Chronic Sinusitis with Nasal Polyp

Purpose of Review

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and heterogeneous inflammatory disease. The underlying epigenetic...

Tiancong Liu, Yang Sun, Weiliang Bai in Current Allergy and Asthma Reports

Article 24 November 2020

Transcriptional Regulation in the Control of Aging and Longevity

Abstract

Transcription regulation is required for correct differential gene expression, which determines the development and function of all cells in...

O. Y. Rybina, E. G. Pasyukova in Advances in Gerontology

Article 01 December 2023

Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma

Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations...

Robert Siddaway, Laura Canty, ... Cynthia Hawkins in Acta Neuropathologica

Article Open access 07 September 2022

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function,...

Qian Ding, Wei Hu, ... Yi Zhun Zhu in Signal Transduction and Targeted Therapy

Article Open access 17 February 2023

Genetic polymorphisms and gene expression of one-carbon metabolizing enzymes and their relation to breast cancer

Background

Breast cancer is considered the leading cause of cancer-related death among Egyptian women (15.41%). One of the common BC risk factors is...

Mona Kamal Eldeeb, Mai Maher Abd-Elaziz Shoaib, ... Radwa Mohammed Rashad in Egyptian Journal of Medical Human Genetics

Article Open access 23 May 2022

Emerging Role of RNA m5C Modification in Cardiovascular Diseases

Epitranscriptomics is the emerging field of research that comprises the study of epigenetics changes in RNAs. Progressing development in the field of...

Kannan Balachander, Jayaseelan Vijayashree Priyadharsini, ... Arumugam Paramasivam in Journal of Cardiovascular Translational Research

Article 01 November 2022

Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation

DNA methyltransferase inhibitors (DNMTi) approved for older AML patients are clinically tested in combination with histone deacetylase inhibitors...

Nadja Blagitko-Dorfs, Pascal Schlosser, ... Michael Lübbert in Leukemia

Article 23 November 2018

Metabolic memory: mechanisms and diseases

Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials...

Hao Dong, Yuezhang Sun, ... Qi Wang in Signal Transduction and Targeted Therapy

Article Open access 28 February 2024