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Preclinical evaluation of [18F]SYN1 and [18F]SYN2, novel radiotracers for PET myocardial perfusion imaging
BackgroundPositron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery...
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cGMP compliant one-step, one-pot automated [18F]FBnTP production for clinical imaging of mitochondrial activity
Background4-[ 18 F]fluorobenzyl-triphenylphosphonium ([ 18 F]FBnTP) is a lipophilic cation PET tracer. The cellular uptake of [ 18 F]FBnTP is correlated...
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89Zr-leukocyte labelling for cell trafficking: in vitro and preclinical investigations
BackgroundThe non-invasive imaging of leukocyte trafficking to assess inflammatory areas and monitor immunotherapy is currently generating great...
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On site production of [18F]PSMA-1007 using different [18F]fluoride activities: practical, technical and economical impact
BackgroundProstate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission...
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Time-related study on external exposure dose of 2-deoxy-2-[F-18]fluoro-d-glucose PET for workers’ safety
Time-course study of individual dose equivalents of 2-deoxy-2-[F-18]fluoro- d -glucose positron emission tomography ( 18 F-FDG PET) was conducted in...
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Transforming an Academic Radiochemistry Facility for Positron Emission Tomography Drug cGMP Compliance
In light of the United States Food and Drug Administration (FDA) requirement of 21 CFR 212 current Good Manufacturing Practice (cGMP) for...
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Engineering a modular 44Ti/44Sc generator: eluate evaluation in preclinical models and estimation of human radiation dosimetry
Background44 Sc/ 47 Sc is an attractive theranostic pair for targeted in vivo positron emission tomographic (PET) imaging and beta-particle treatment...
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Imaging of cardiac sympathetic dysfunction with 18F-FDOPA PET/CT in patients with heart failure: a pilot study
BackgroundRoutine use of cardiac sympathetic imaging in HF has been limited by the lower availability/sensitivity of radiotracers. This study was...
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A comparison study of dynamic [18F]Alfatide II imaging and [11C]MET in orthotopic rat models of glioblastoma
PurposeTo investigate and compare the dynamic positron emission tomography (PET) imaging with [ 18 F]Alfatide II Imaging and [ 11 C]Methionine ([ 11 C]MET)...
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Current status and perspectives of nuclear cardiology
Nuclear cardiology has long been used to identify myocardial ischemia for appropriate treatment strategies for stable coronary artery disease (CAD)....
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Therapeutic Effects of Lipid Lowering Medications on Myocardial Blood Flow, Inflammation, and Sympathetic Nerve Activity Using Nuclear Techniques
Purpose of ReviewStatins are routinely applied in patients with coronary artery disease, as they allow significantly to reduce blood cholesterol...
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
BackgroundThe brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of...
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Creation, evolution, and future challenges of ion beam therapy from a medical physicist’s viewpoint (Part 3): Chapter 3. Clinical research, Chapter 4. Future challenges, Chapter 5. Discussion, and Conclusion
Clinical studies of ion beam therapy have been performed at the Lawrence Berkeley Laboratory (LBL), National Institute of Radiological Sciences...
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Experience of 6-l-[18F]FDOPA Production Using Commercial Disposable Cassettes and an Automated Module
PurposeThe clinical demand of 6 - l -[ 18 F] FDOPA is gaining rapidly for imaging neurodegenerative diseases by using positron emission tomography....
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High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET
BackgroundSodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing...
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The utility of PET for detecting corticotropinomas in Cushing disease: a sco** review
While magnetic resonance imaging (MRI) is the current standard imaging method for diagnosing and localizing corticotropinomas in Cushing disease, it...