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The priorities, challenges, and scope of clinical communication teaching perceived by clinicians from different disciplines: a Hong Kong case study
BackgroundIn the absence of a well-rounded syllabus that emphasises both interpersonal and medical dimensions in clinical communication, medical...
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Pediatric hemispheric cerebellar low-grade gliomas: clinical approach, diagnosis, and management challenges—experience at a tertiary care children’s hospital
PurposeThis study aims to provide an exhaustive analysis of pediatric low-grade gliomas (pLGGs) in the cerebellar hemispheres, focusing on incidence,...
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Radiomics workflow definition & challenges - German priority program 2177 consensus statement on clinically applied radiomics
ObjectivesAchieving a consensus on a definition for different aspects of radiomics workflows to support their translation into clinical usage....
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Fibroblast activation protein-targeted radionuclide therapy: background, opportunities, and challenges of first (pre)clinical studies
IntroductionFibroblast activation protein (FAP) is highly overexpressed in stromal tissue of various cancers. While FAP has been recognized as a...
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Prostate Cancer in Transgender Women: Epidemiology, Clinical Characteristics, and Management Challenges
Purpose of ReviewTo systematically review the evidence on prostate cancer (PCa) in transgender women (TGW).
Recent FindingsA total of 25 studies...
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Therapeutic cancer vaccines: advancements, challenges, and prospects
With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies, cancer immunotherapy has undergone a...
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A Review of ADHD and Childhood Trauma: Treatment Challenges and Clinical Guidance
Purpose of ReviewThere has been increasing interest about the link between attention-deficit/hyperactivity disorder (ADHD) and childhood trauma. This...
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Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects—challenges for future studies
Osteoarthritis (OA) is one of the most common and socioeconomically relevant diseases, with rising incidence and prevalence especially with regard to...
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Diabetes mellitus in patients with acromegaly: pathophysiology, clinical challenges and management
Acromegaly is a rare endocrine disease caused by hypersecretion of growth hormone, most commonly arising due to a pituitary adenoma. Diabetes...
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Emulating a Target Trial in Perinatal Pharmacoepidemiology: Challenges and Methodological Approaches
Purpose of ReviewThe objective of this review is to examine the application of target trial emulation in perinatal pharmacoepidemiology research....
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Incorporating patient-reported outcome measures (PROMs) into a clinical quality registry (CQR) for ovarian cancer: considerations and challenges
As medical treatment increasingly focuses on improving health-related quality of life, patient-reported outcome measures (PROMs) are an essential...
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Challenges for a broad international implementation of the current severe community-acquired pneumonia guidelines
Severe community-acquired pneumonia (sCAP) remains one of the leading causes of admission to the intensive care unit, thus consuming a large share of...
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Artificial intelligence in neurology: opportunities, challenges, and policy implications
Neurological conditions are the leading cause of disability and mortality combined, demanding innovative, scalable, and sustainable solutions. Brain...
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Radiomics in medical imaging: pitfalls and challenges in clinical management
BackgroundRadiomics and radiogenomics are two words that recur often in language of radiologists, nuclear doctors and medical physicists especially...
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Transforming neonatal care with artificial intelligence: challenges, ethical consideration, and opportunities
Artificial intelligence (AI) offers tremendous potential to transform neonatology through improved diagnostics, personalized treatments, and earlier...
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Recessive cerebellar and afferent ataxias — clinical challenges and future directions
Cerebellar and afferent ataxias present with a characteristic gait disorder that reflects cerebellar motor dysfunction and sensory loss. These...
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Overcoming challenges in conducting systematic reviews in implementation science: a methods commentary
Consolidation of the literature using systematic reviews is a critical way to advance a discipline and support evidence-based decision-making in...
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Pediatrics in Artificial Intelligence Era: A Systematic Review on Challenges, Opportunities, and Explainability
BackgroundThe emergence of artificial intelligence (AI) tools such as ChatGPT and Bard is disrupting a broad swathe of fields, including medicine. In...
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Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges
Dimethyl sulfoxide (DMSO) is a clear, odorless liquid, inexpensively produced as a by-product of the wood pulp industry. DMSO’s unique chemical...
