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Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer
Growing evidence indicates that lncRNA colon cancer-associated transcript 2 (CCAT2) is associated with cancers. However, the clinical value of CCAT2...
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The characteristics and clinical relevance of tumor fusion burden in non-EBV (+) gastric cancer with MSS
BackgroundNext-generation sequencing (NGS) is maturely applied for gene fusion detection. Although tumor fusion burden (TFB) has been identified as...
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Human papillomavirus (HPV) integration signature in cervical lesions: identification of MACROD2 gene as HPV hot spot integration site
BackgroundHigh-risk HPV is clearly associated with cervical cancer. Integration of HPV DNA into the host genome is considered a key event in driving...
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Microsatellite instability (MSI-H) is associated with a high immunoscore but not with PD-L1 expression or increased survival in patients (pts.) with metastatic colorectal cancer (mCRC) treated with oxaliplatin (ox) and fluoropyrimidine (FP) with and without bevacizumab (bev): a pooled analysis of the AIO KRK 0207 and RO91 trials
IntroductionIn a retrospective analysis of two randomized phase III trials in mCRC patients treated first line with oxaliplatin, fluoropyrimidine...
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Somatic ARID1A mutation stratifies patients with gastric cancer to PD-1 blockade and adjuvant chemotherapy
BackgroundAT-rich interaction domain 1A (ARID1A) encodes a vital component of switch/sucrose non-fermentable chromatin-remodeling complex. Given its...
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The Effect of RAS/BRAF Mutation Status on Prognosis and Relapse Pattern in Early Stage Colon Cancers
PurposeIt is known that the RAS and BRAF mutations are predictive for targeted therapies in treating metastatic colon cancer and negatively affect...
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Genomic ancestry and cancer among Latin Americans
Latin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native...
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Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy
Tumor immunogenicity is driven by various genomic and transcriptomic factors but the association with the overall status of methylation aberrancy is...
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Global research trends on the relationship between IBD and CRC: a bibliometric analysis from 2000 to 2023
ObjectiveThis study aimed to conduct a bibliometric analysis of research articles on the relationship between inflammatory bowel disease (IBD) and...
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Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma
BackgroundMucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and...
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Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer
Deficient mismatch repair (dMMR)/microsatellite instability (MSI) colorectal cancer (CRC) has high immunogenicity and better prognosis compared with...
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HPV-associated cancers: insights into the mechanistic scenario and latest updates
Cancer and related diseases are the second leading cause of death worldwide. The human papillomavirus (HPV) is an infectious agent that can be spread...
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Determinants and clinical implications of chromosomal instability in cancer
Aberrant chromosomal architecture, ranging from small insertions or deletions to large chromosomal alterations, is one of the most common...
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Current Understanding and Management of Intraductal Carcinoma of the Prostate
Purpose of ReviewThis review will discuss current understanding and management approaches of Intraductal carcinoma of the prostate (IDC-P). IDC-P is...
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Current status of immunotherapy in gastric cancer
Gastric cancer is one of the most common cancer with high mortality and morbilidity in East Asia, especially in China. In recent year, new treatment...
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Human epidermal growth factor 2 overexpressed alpha-fetoprotein-producing-gastric cancer
PurposeThis study aimed to elucidate the clinicopathological characteristics of α-fetoprotein (AFP)-producing gastric carcinoma (AFP-GC) with human...
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Immune checkpoint blockade therapy for BRAF mutant metastatic colorectal cancer: the efficacy, new strategies, and potential biomarkers
BRAF mutant metastatic colorectal cancer has long been considered a tumor with a poor prognosis and a poor response to chemotherapy. Despite the...
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Centrosome loss results in an unstable genome and malignant prostate tumors
Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of...
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Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying...
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CINSARC signature outperforms gold-standard TNM staging and consensus molecular subtypes for clinical outcome in stage II–III colorectal carcinoma
The outcome of stage II–III colorectal cancer (CRC) is highly variable and therapeutic choice is currently based on TNM staging with a few additional...
