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Liver cancer wars: plant-derived polyphenols strike back
Liver cancer currently represents the leading cause of cancer-related death worldwide. The majority of liver cancer arises in the context of chronic...
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New Avenues for Treatment and Prevention of Drug-Induced Steatosis and Steatohepatitis: Much More Than Antioxidants
Drug-induced lipid accumulation in the liver may induce two clinically relevant conditions, drug-induced steatosis (DIS) and drug-induced...
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A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis
BackgroundLiver cirrhosis is a chronic liver disease with hepatocyte necrosis and lesion. As one of the TCM formulas Wuling Powder (WLP) is widely...
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Preclinical targeting of liver fibrosis with a 89Zr-labeled Fibrobody® directed against platelet derived growth factor receptor-β
PurposeHepatic fibrosis develops as a response to chronic liver injury, resulting in the formation of fibrous scars. This process is initiated and...
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The human microbiome and gut–liver axis in people living with HIV
Purpose of ReviewChronic liver disease is a major cause of morbidity and mortality amongst people living with HIV (PLWH). Emerging data suggests that...
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Pulmonary Complications of the Liver
Purpose of ReviewHepatic hydrothorax (HH), hepatopulmonary syndrome (HPS), and portopulmonary hypertension (PoPH) are the most common complications...
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Bile Duct Injury Due to Drug-Induced Liver Injury
Purpose of ReviewDrug-induced liver injury (DILI) can present with a variable clinical and pathological phenotype and can be classified using liver...
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Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice
BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver disease worldwide. Si-Wu-Tang (SWT), a...
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Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast
BackgroundIn recent years, spectral CT-derived liver fat quantification method named multi-material decomposition (MMD) is playing an increasingly...
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Protective effects of pioglitazone in renal ischemia–reperfusion injury (RIRI): focus on oxidative stress and inflammation
BackgroundRenal ischemia-reperfusion injury (RIRI) is a critical phenomenon that compromises renal function and is the most serious health concern...
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Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study
Ethnopharmacological relevancePsoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of...
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The ameliorating effect of Rutin on hepatotoxicity and inflammation induced by the daily administration of vortioxetine in rats
BackgroundVortioxetine (VORTX) is a potent and selective type of selective serotonin reuptake inhibitor (SSRI) that is mainly prescribed for treating...
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Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In the...
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Outcomes, Attitudes, and Updated Ethical Analysis of Early Liver Transplantation for Severe Alcoholic Hepatitis
Purpose of ReviewEarly liver transplantation (ELT) refers to transplantation for alcohol-related liver disease (ALD) that takes place before 6 months...
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Key CT and MRI findings of drug-associated hepatobiliary and pancreatic disorders
Obtaining an imaging diagnosis of various hepatobiliary and pancreatic disorders caused by certain drugs can often be challenging. Familiarity with...
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Hippo signalling in the liver: role in development, regeneration and disease
The Hippo signalling pathway has emerged as a major player in many aspects of liver biology, such as development, cell fate determination,...
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The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl4-induced liver injury in male rats
BackgroundOxidative stress (OS) and inflammation are the central pathogenic events in liver diseases. In this study, the protective and therapeutic...
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Protective effect of selenomethionine on T-2 toxin-induced liver injury in New Zealand rabbits
BackgroundT-2 toxin is a mycotoxin produced by Fusarium species that is highly toxic to animals. Recent studies have indicated that Selenomethionine...
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The Function of Circular RNAs in Myocardial Ischemia–Reperfusion Injury: Underlying Mechanisms and Therapeutic Advancement
Myocardial ischemia reperfusion injury (MIRI) represents a prevalent and severe cardiovascular condition that arises primarily after myocardial...
