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Management of Giant Cell Tumor of Distal Radius—Does Curettage Work?
Giant cell tumor affecting distal radius has been considered more aggressive, as compared to its counterparts in other locations. While resection has...
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STING is a prognostic factor related to tumor necrosis, sarcomatoid dedifferentiation, and distant metastasis in clear cell renal cell carcinoma
STING is a molecule involved in immune reactions against double-stranded DNA fragments, released in infective and neoplastic diseases, whose role in...
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Diagnostic utility of CSF1 immunohistochemistry in tenosynovial giant cell tumor for differentiating from giant cell-rich tumors and tumor-like lesions of bone and soft tissue
BackgroundTenosynovial giant cell tumor (TSGCT) is a benign fibrohistiocytic tumor that affects the synovium of joints, bursa, and tendon sheaths and...
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Analysis of the immunological markers BTLA, TIM-3, and PD-L1 at the invasion front and tumor center in clear cell renal cell carcinoma
PurposeImmune checkpoint inhibitors (ICI) are then backbone in the therapy of metastatic renal cell carcinoma (RCC). The aim of this analysis was to...
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Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid
Detection of peritoneal dissemination (PD) in gastric cancer (GC) patients remains challenging. The feasibility of tumor-guided cell-free DNA (cfDNA)...
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Partial sternectomy with reconstruction of a giant cell tumor of the sternum, a case report, Saudi, Arabia
BackgroundGiant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor that rarely affects the sternum.
Case presentation ...
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Giant Cell Tumor of the Mandible: A Case Report with an Argument on a Possible Diagnostic Tool
Giant cell tumor (GCT) is a benign, locally aggressive neoplasm with a high recurrence rate with common occurrence in the long bone and the cases in...
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Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
BackgroundT cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumors remain refractory....
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The sclerosing sertoli cell tumor of the testis: a case report
BackgroundTesticular Sertoli cell tumor (SCT) is very rare sex cord-gonadal stromal tumor, and sclerosing SCT (SSCT) is even rarer. So far, no more...
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Large Congenital Granular Cell Tumor in the Newborn—Diagnosis and Management: Case Report and Literature Review
AbstractThe congenital granular cell tumor is a benign soft tissue lesion, unique to the newborn, which originates from the mucosa of the alveolar...
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Predictive value of tumor budding in head and neck squamous cell carcinoma: an update
Head and neck squamous cell carcinoma forms an anatomically and functionally complex group of malignancies. The significant local aggressiveness and...
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Implications of single-cell immune landscape of tumor microenvironment for the colorectal cancer diagnostics and therapy
Colorectal cancer (CRC) originates from the polyps lining the colon and is among the most common types of cancer. With the increasing popularity of...
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Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
While Stimulator-of-interferon genes (STING) is an innate immune adapter cruicial for sensing cytosolic DNA and modulating immune microenvironment,...
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and...
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The long-term outcomes of local tumor destruction versus partial nephrectomy for cT1a non-clear cell renal cell carcinoma and development of prognostic nomograms
PurposeThere is a lack of authoritative opinions on local tumor destruction (LTD) for clinical T1a (cT1a) non-clear cell renal cell carcinoma...
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Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis
The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their...
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Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Tumor thrombus of bone sarcomas represents a unique reservoir for various types of cancer and immune cells, however, the investigation of tumor...
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Cytodiagnostic Dilemma in a Lung Mass as the First Presentation of Testicular Mixed Germ Cell Tumor Metastasis
Testicular mixed germ cell tumors (TMGCTs) are rare malignant tumors comprising of two or more types of germ cell tumors. Their onset may be...
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LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway
LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney...
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A case of adult granulosa cell tumor presenting as thoracic lesions
BackgroundGranulosa cell tumors (GCTs) are uncommon sex cord-stromal ovarian neoplasms. We report a case of GCT presenting in the chest, 18 years...
