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Electrophysiological insights into the relationship between calcium dynamics and cardiomyocyte beating function in chronic hemodialysis treatment
For patients in which the Ca 2+ concentration of dialysis fluid is lower than that in plasma, chronic hemodialysis treatment often leads to cardiac...
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Intracellular O-linked glycosylation directly regulates cardiomyocyte L-type Ca2+ channel activity and excitation–contraction coupling
Cardiomyocyte L-type Ca 2+ channels (Ca v s) are targets of signaling pathways that modulate channel activity in response to physiologic stimuli. Ca v ...
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Reprogramming of Non-myocytes into Cardiomyocyte-like Cells: Challenges and Opportunities
Purpose of ReviewThe high global incidence of heart disease drives the need for methods of mending damaged hearts. Direct reprogramming of cardiac...
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DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly...
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Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair
Adult mammalian cardiomyocytes have minimal cell cycle capacity, which leads to poor regeneration after cardiac injury such as myocardial infarction....
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Cardiomyocyte microvesicles: proinflammatory mediators after myocardial ischemia?
Myocardial infarction is a frequent complication of cardiovascular disease leading to high morbidity and mortality worldwide. Elevated C-reactive...
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Cardiac-specific methylation patterns of circulating DNA for identification of cardiomyocyte death
BackgroundCorrect detection of human cardiomyocyte death is essential for definitive diagnosis and appropriate management of cardiovascular diseases....
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METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes
BackgroundHypoxia/reoxygenation (H/R) induces cardiomyocyte ferroptosis, a core remodeling event in myocardial ischemia/reperfusion injury....
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Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmental metabolic changes, the...
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LncRNAMORT is upregulated in myocardial infarction and promotes the apoptosis of cardiomyocyte by downregulating miR-93
BackgroundMyocardial infarction (MI) affects the expression of a large number of lncRNAs, while the functions of those dysregulated lncRNAs are...
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Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac...
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Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Activation of gasdermin D (GSDMD) and its concomitant cardiomyocyte pyroptosis are critically involved in multiple cardiac pathological conditions....
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Effects of obstructive sleep apnea on myocardial injury and dysfunction: a review focused on the molecular mechanisms of intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH) and is strongly associated with adverse cardiovascular outcomes....
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MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes
BackgroundCardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated...
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Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury
Reperfusion modality can cause damage to cardiomyocytes, known as myocardial ischemia–reperfusion injury (MI/RI). Circular RNAs (circRNAs) are...
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Transmembrane protein 117 knockdown protects against angiotensin-II-induced cardiac hypertrophy
Mitochondrial dysfunction plays a critical role in the pathogenesis of pathological cardiac hypertrophy. Transmembrane protein 117 modulate...
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The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling
Rehabilitation exercise is a crucial non-pharmacological intervention for the secondary prevention and treatment of cardiovascular diseases,...
