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Rationale and Design of the SOTA-P-CARDIA Trial (ATRU-V): Sotagliflozin in HFpEF Patients Without Diabetes
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure (HF). This syndrome is associated with an...
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A narrative review of the mechanisms and consequences of intermittent hypoxia and the role of advanced analytic techniques in pediatric autonomic disorders
Disorders of autonomic functions are typically characterized by disturbances in multiple organ systems. These disturbances are often comorbidities of...
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Cardiovascular toxicity of checkpoint inhibitors: review of associated toxicity and design of the Spanish Immunotherapy Registry of Cardiovascular Toxicity
Immune checkpoint inhibitors (ICI) have changed the prognosis of many tumors. However, concerning associated cardiotoxicity has been reported. Little...
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Pericarditis Management in Individuals Contemplating Pregnancy, Currently Pregnant, or Breastfeeding
Purpose of ReviewPericarditis complicates pregnancy planning, pregnancy, or the postpartum period, and the management approach requires special...
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Effect of Nicorandil, Diltiazem, or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts—A Pilot Randomized Controlled Trial (ASRAB-Pilot): Rationale and Study Protocol
IntroductionThe current evidence for chronic oral antispastic medication use after coronary artery bypass grafting using radial artery grafts...
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Paediatric autoimmune diseases with ELANE mutations associated with neutropenia
ObjectiveTo explore the clinical characteristics of autoimmune diseases in children with ELANE mutations.
MethodsThree cases of children with ELANE...
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Remission of type 2 diabetes: position statement of the Italian society of diabetes (SID)
The primary cause of the pandemic scale of type 2 diabetes (T2D) is the excessive and/or abnormal accumulation of adiposity resulting from a chronic...
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Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure
Immune checkpoint molecules are physiological regulators of the adaptive immune response. Immune checkpoint inhibitors (ICIs), such as monoclonal...
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Approach to the Older Patient with Acute Myeloid Leukemia
Purpose of ReviewThis study aims to review the challenges of treating AML in older patients, the spectrum of genomic aberrancies in this cohort, and...
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Association of Repetitive Dosing of Levosimendan with Reduction of NYHA Class and NT-proBNP Levels in Decompensated Heart Failure: A Retrospective Cohort Study
BackgroundThere is evidence that repetitive administration of levosimendan can improve outcome in chronic heart failure patients.
Objective ...
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Prenatal diagnosis, associated findings and postnatal outcome of fetuses with truncus arteriosus communis (TAC)
PurposeTo assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with truncus arteriosus...
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VEGF Receptor Inhibitor-Induced Hypertension: Emerging Mechanisms and Clinical Implications
Purpose of ReviewWhile vascular endothelial growth factor receptor inhibitors (VEGFRis) have dramatically improved cancer survival, these drugs cause...
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Dietary total antioxidant capacity interacts with a variant of chromosome 5q13-14 locus to influence cardio-metabolic risk factors among obese adults
BackgroundThe association between cocaine- and amphetamine-regulated transcript prepropeptide gene (CARTPT) and obesity-related outcomes has shown in...
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Coronary Artery Disease in Women—Review of Risk Factors and Emerging Concepts
Purpose of ReviewCoronary artery disease (CAD) in women is an evolving area of interest in cardiovascular medicine. This review seeks to provide a...
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Quantitative analysis of cell-free plasma DNA as a prognostic biomarker in acute ischemic stroke patients
BackgroundStroke has become a leading cause of death and disability worldwide, and despite the introduction of new screening programs, therapies, and...
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Effect of sodium–glucose cotransporter 2 inhibitors on insulin resistance; a systematic review and meta-analysis
AimRecent studies have indicated that Sodium–GLucose co-Transporter 2 Inhibitors (SGLT2Is) may increase insulin sensitivity (IS); however, these...
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Controversies in enhanced recovery after cardiac surgery
Advances in cardiac surgical operative techniques and myocardial protection have dramatically improved outcomes in the past two decades. An...
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New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury
Advancements in pediatric dialysis generally rely on adaptation of technology originally developed for adults. However, in the last decade,...
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Anesthetic Management in Adults with Congenital Heart Disease
Purpose of ReviewAdults with congenital heart disease (ACHD) are a complex and growing population that presents numerous challenges for anesthetic...
