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Association of serum interleukin-2 with severity and prognosis in hospitalized patients with community-acquired pneumonia: a prospective cohort study
The prior studies have shown that interleukin-2 (IL-2) exerts important roles in the pathological and physiological processes of lung diseases....
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Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas
PurposeThe purpose of the study was to evaluate the prognostic value of low T3 syndrome in peripheral T-cell lymphomas (PTCLs).
Methods ...
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Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia
ObjectiveCommunity-acquired pneumonia (CAP) is the primary cause of death for children under five years of age globally. Hence, it is essential to...
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Opsin 3 expression in human Langerhans cell histiocytosis and its mediation of ELD-1 cellular function
BackgroundLangerhans cell histiocytosis (LCH) is a type of histiocytic disorder characterized by aberrant function, differentiation or proliferation...
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Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series
There are no definitive therapies for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Therefore, new...
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When chronic obstructive pulmonary disease meets small cell lung cancer: an unusual case report of rapid progression
BackgroundChronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease and a risk factor for lung cancer. Small cell lung cancer is...
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Targeting immune cell recruitment in atherosclerosis
Atherosclerosis is the primary underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular disease is characterized by a...
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Clear cell meningiomas—case presentation, review of radiographic identifiers, and treatment approaches
Spinal clear cell meningiomas (CCMs) are a rare histological subtype of meningiomas that pose preoperative diagnostic challenges due to their...
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Enhancing drug and cell line representations via contrastive learning for improved anti-cancer drug prioritization
Due to cancer’s complex nature and variable response to therapy, precision oncology informed by omics sequence analysis has become the current...
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Captopril pretreatment augments diabetogenic response to streptozotocin administration: experimental in vivo rat model
BackgroundStreptozotocin (STZ) is a glucose analogue commonly used for inducing diabetes in experimental animals. This study is intended to...
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Superiority of polatuzumab vedotin over other novel agents in previously untreated ABC-type diffuse large B-cell lymphoma: a network meta-analysis of 20 RCTs
Because of lacking of head-to-head comparison among polatuzumab (Pola) vedotin and other novel agents for untreated diffuse large B-cell lymphoma...
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Childhood community-acquired pneumonia
Community-acquired pneumonia (CAP) is a common disease in children, and its aetiological and clinical diagnosis are challenging for physicians in...
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Corneal endothelial cell density and associated factors among adults at a regional referral hospital in Uganda: a cross-sectional study
BackgroundTo assess the prevalence of low corneal endothelial cell density and correlates of corneal endothelial cell density among adults attending...
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Significance of Worst Pattern of Invasion-5 in Early-Stage Oral Cavity Squamous Cell Carcinoma
BackgroundThere is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection...
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Validation of the VisionArray® Chip Assay for HPV DNA Testing in Histology Specimens of Oropharyngeal Squamous Cell Carcinoma
BackgroundThe detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous...
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mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death
Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, we show that mTOR inhibition...
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Effect of prior lenalidomide or daratumumab exposure on hematopoietic stem cell collection and reconstitution in multiple myeloma
BackgroundThe roles of Lenalidomide (Len) and Daratumumab (Dara) in multiple myeloma treatment are well-established, yet their influences on...
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Selection of M7G-related lncRNAs in kidney renal clear cell carcinoma and their putative diagnostic and prognostic role
BackgroundKidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. This study aims to develop new biomarkers for...
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Characteristics of rabbit hapten-specific and germline-based BCR repertoires following repeated immunization
The rabbit is well known for producing diverse antibodies against various antigens including small molecules such as drugs and toxins, due to a...
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The association between inflammatory biomarkers and carotid artery plaque in normal-weight and metabolically healthy Chinese adults: a cross-sectional study
Existing evidence has indicated a role of inflammation in the development of carotid artery plaque (CAP). We thus evaluated the association between...
