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The decisive early phase of bone regeneration
Bone has a remarkable endogenous regenerative capacity that enables scarless healing and restoration of its prior mechanical function, even under...
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Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models
Loss of bone is a common medical problem and, while it can be treated with available therapies, some of these therapies have critical side effects....
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The aetiology of atypical bone health in individuals with Down syndrome
PurposeTrisomy 21 (T21), more commonly known as Down syndrome (DS) is a genetic condition where every cell in the body has an additional copy of...
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Impact of urinary calcium excretion on kidney, bone, and cardiovascular systems in patients with bone biopsy proven osteoporosis: a longitudinal long-term follow-up study
SummaryThe impact of urine calcium on kidney, bone, and cardiovascular systems in osteoporosis is not well-known. In this 7-year-follow-up study,...
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Disorganization and Musculoskeletal Diseases: Novel Insights into the Enigma of Unexplained Bone Abnormalities and Fragility Fractures
Purpose of ReviewDescribe the potential contribution of disorganized tissue to the pathogenesis of bone abnormalities and fractures. Especially,...
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Small-molecule amines: a big role in the regulation of bone homeostasis
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they...
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Hallmarks of peripheral nerve function in bone regeneration
Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and...
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Low frequency pulsed electromagnetic fields exposure alleviate the abnormal subchondral bone remodeling at the early stage of temporomandibular joint osteoarthritis
BackgroundTemporomandibular joint osteoarthritis (TMJOA) is characterized by abnormal subchondral bone remodeling and cartilage degeneration. As a...
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The relationship between coronary artery calcification and bone metabolic markers in maintenance hemodialysis patients
BackgroundTo study the influencing factors for coronary artery calcification (CAC) in maintenance hemodialysis (MHD) patients and the relationship...
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Recent Advances in the Role of Diet in Bone and Mineral Disorders in Chronic Kidney Disease
Purpose of ReviewChronic kidney disease mineral and bone disease (CKD-MBD) is a common complication of kidney disease and is strongly influenced by...
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Variable Bone Phenotypes in Patients with Pseudohypoparathyroidism
Purpose of ReviewPseudohypoparathyroidism (PHP) is a disorder caused by mutations and/or epigenetic changes at the complex GNAS locus. It is...
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Relationship between DXA measured systemic bone mineral density and subchondral bone cysts in postmenopausal female patients with knee osteoarthritis: a cross-sectional study
BackgroundIndividuals with high systemic bone mineral density (BMD) may have an increased risk of incident knee osteoarthritis (OA). Besides that,...
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Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling
Despite the diverse roles of tripartite motif (Trim)-containing proteins in the regulation of autophagy, the innate immune response, and cell...
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Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone
Denosumab, a human monoclonal antibody against receptor activator of nuclear factor-κB ligand (RANKL), is a potent inhibitor of osteoclast...
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Update on the utility of trabecular bone score (TBS) in clinical practice for the management of osteoporosis: a systematic review by the Egyptian Academy of Bone and Muscle Health
Trabecular bone score (TBS) is a grayscale textural assessment resulting from a computed evaluation of pixel gray-level variations in previously...
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Investigation of the optimal light parameters for photobiomodulation to induce osteogenic differentiation of the human bone marrow stem cell and human umbilical vein endothelial cell co-culture
Bones have an important role in the human body with their complex nature. Mesenchymal stem cells and endothelial cells together support their unique...
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Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis
Phellodendron (PN) species, traditionally used in Chinese medicine for centuries, hold promise as a potential treatment for osteoporosis (OP) and...
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Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the...
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Effect of physical therapy on bone remodelling in preterm infants: a multicenter randomized controlled clinical trial
BackgroundPreterm infants have a low level of bone mineralization compared to those born at term, since 80% of calcium incorporation occurs at the...
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Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption
BackgroundAngiogenesis is regarded as a critical role in bone repair and regeneration, involving in pathological bone disorders such as osteoporosis....
