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ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
Aims/hypothesisZBED6 (zinc finger, BED-type containing 6) is known to regulate muscle mass by suppression of Igf2 gene transcription. In...
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Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice
Aims/hypothesisIslets have complex heterogeneity and subpopulations. Cell surface markers representing alpha, beta and delta cell subpopulations are...
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Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange
BackgroundUnderstanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This study aims to...
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Association of serum osteocalcin with beta cell function, insulin resistance, and glycemic parameters in south Indian type 2 diabetic subjects
BackgroundOsteocalcin (OC), also known as bone Gla (gamma-carboxyglutamic acid) protein, is a marker of bone formation. OC has effect on glucose and...
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Markers of Endothelial Dysfunction in Kawasaki Disease: An Update
Kawasaki disease (KD) is a medium vessel vasculitis that has a special predilection for coronary arteries. Cardiovascular complications include the...
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Beta-blocker efficacy for intra- and interdialytic hypertension patients: a systematic review and meta-analysis
PurposeIntradialytic hypertension affects 5–15% of hemodialysis patients, yet relevant studies are relatively scarce. It is also associated with...
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Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway
BackgroundAtherosclerosis (AS) is the primary cause of cardiovascular disease and the incidence is extremely common; however, there are currently few...
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TFR1 knockdown alleviates iron overload and mitochondrial dysfunction during neural differentiation of Alzheimer’s disease-derived induced pluripotent stem cells by interacting with GSK3B
Iron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1)...
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Renal dysfunction caused by severe hypothyroidism diagnosed by renal biopsy: a case report
There is a close relationship between thyroid dysfunction and renal dysfunction. However, thyroid dysfunction can unfortunately result in inaccurate...
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Myofilament dysfunction in diastolic heart failure
Diastolic heart failure (DHF), in which impaired ventricular filling leads to typical heart failure symptoms, represents over 50% of all heart...
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Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition
Endothelial dysfunction is an early event in coronary microvascular disease. Integrin-linked kinase (ILK) prevents endothelial nitric oxide synthase...
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Maturation of beta cells: lessons from in vivo and in vitro models
The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However,...
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M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice
Aims/hypothesisMacrophage levels are elevated in pancreatic islets, and the resulting inflammatory response is a major contributor to beta cell...
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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Synapse loss correlates with cognitive decline in Alzheimer’s disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction...
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Endothelial cell dysfunction: a key determinant for the outcome of allogeneic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (alloSCT) carries the promise of cure for many malignant and non-malignant diseases of the...
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Anesthesia, Anesthetics, and Postoperative Cognitive Dysfunction in Elderly Patients
Postoperative cognitive dysfunction (POCD) remains a major issue that worsens the prognosis of elderly surgery patients. This article reviews the...
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Intestinal Barrier Dysfunction in Inflammatory Bowel Disease: Underpinning Pathogenesis and Therapeutics
The intestinal barrier is composed of several essential elements including luminal enzymes, bile acids, water layer, epithelial layer, and enterocyte...
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Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta1-42 in mice
BackgroundAmyloid-β 1-42 (Aβ 1-42 ) plays an essential role in the development of the early stage of Alzheimer’s disease (AD). Asiatic acid (AA), an...
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Prevalence of thyroid nodule and its association with β-cell autoantibodies in adult patients with type 1 diabetes mellitus without thyroid dysfunction
ObjectiveAlthough many studies have shown the relationship between type 1 diabetes mellitus (T1DM) and autoimmune thyroid diseases, few studies have...
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Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes
ObjectiveType 2 diabetes (T2D) is a chronic low-grade inflammatory disease, which characterized by islet beta cell dysfunction. Serum adenosine...
