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In search for biomarkers and potential drug targets for uterine serous endometrial cancer
ObjectiveSerous endometrial cancer (USC) is a challenging malignancy associated with metastasis, recurrence and poor outcome. To identify clinically...
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P4HA2 activates mTOR via hydroxylation and targeting P4HA2-mTOR inhibits lung adenocarcinoma cell growth
Mammalian target of rapamycin (mTOR) kinase functions as a central regulator of cell growth and metabolism, and its complexes mTORC1 and mTORC2...
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The importance of personalized medicine in chronic myeloid leukemia management: a narrative review
BackgroundTyrosine kinase inhibitors (TKIs) are prescribed as a targeted therapy to treat chronic myeloid leukemia patients. A challenge in clinical...
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Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer
BackgroundGenomic instability is a hallmark of cancer cells contributing to tumor development and progression. Integrin-linked kinase (ILK) is a...
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Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report
BackgroundUnderstanding the drivers of recurrence in aggressive prostate cancer requires detailed molecular and genomic understanding in order to aid...
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Anti-PD-1-based immunotherapy plus lenvatinib to treat advanced gallbladder cancer in the elderly: a case series and review of current literature
BackgroundGallbladder cancer (GBC) is a rare malignant tumour of the bile duct. Due to the lack of typical clinical manifestations in the early...
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CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties
Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism...
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A framework for fibrolamellar carcinoma research and clinical trials
Fibrolamellar carcinoma (FLC), a rare, lethal hepatic cancer, occurs primarily in adolescents and young adults. Unlike hepatocellular carcinoma, FLC...
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Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer
Overexpression and cellular mis-localization of aurora kinase A (AURKA) in gastrointestinal cancers results in chromosomal instability, activation of...
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Targeting ATR in patients with cancer
Pharmacological inhibition of the ataxia telangiectasia and Rad3-related protein serine/threonine kinase (ATR; also known as FRAP-related protein...
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Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a
BackgroundNGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus....
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Methylation of Aurora kinase A by MMSET reduces p53 stability and regulates cell proliferation and apoptosis
The histone methyltransferase multiple myeloma SET domain protein (MMSET/WHSC1) is highly expressed in diverse tumor types, and its expression...
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Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously challenging to treat and...
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Identification of Novel Small-Molecule Kinase Modulators for the Treatment of Neuroblastoma
Neuroblastoma represents 8–10% of all childhood cancer cases and is responsible for 15% of all cancer-related deaths in infants. Even though patients...
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The yin and yang of chromosomal instability in prostate cancer
Metastatic prostate cancer remains an incurable lethal disease. Studies indicate that prostate cancer accumulates genomic changes during disease...
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Identification of novel candidate genes associated with meiotic aneuploidy in human embryos by whole-exome sequencing
PurposeTo identify novel genetic variants responsible for meiotic embryonic aneuploidy.
MethodsA prospective observational cohort study that...
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The origin and possible mechanism of embryonic cell-free DNA release in spent embryo culture media: a review
The presence of cell-free DNA in spent embryo culture media (SECM) has unveiled its possible utilization for embryonic ploidy determination, opening...
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Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck, with high morbidity and mortality, ranking as the sixth...