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Characteristics and mechanisms of resorption in lumbar disc herniation
Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment. However, the pathogenesis and physiological indications for...
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GEORG SCHMORL PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2018: combined inflammatory and mechanical stress weakens the annulus fibrosus: evidences from a loaded bovine AF organ culture
PurposeThe pathomechanism of annulus fibrosus (AF) failure is still unknown. We hypothesise that mechanical overload and an inflammatory...
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Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway
BackgroundTo identify regulatory ncRNA molecules that can cause differential expression of CDH2 in intervertebral disc degeneration (IDD) and explore...
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Induction of cervical disc degeneration and discogenic pain by low concentration Propionibacterium acnes infection: an in vivo animal study
BackgroundAlthough cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an...
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Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model
Spondylocarpotarsal syndrome (SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions...
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Histology and chronological magnetic resonance images of congenital spinal deformity: An experimental study in mice model
BackgroundThe natural history of the congenital spinal deformity and its clinical magnitude vary widely in human species. However, we previously...
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Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration
PurposeIntervertebral disc degeneration (IDD) is one of the main causes of low back pain, which not only affects patients’ life quality, but also...
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Mechanisms and clinical implications of intervertebral disc calcification
Low back pain is a leading cause of disability worldwide. Intervertebral disc (IVD) degeneration is often associated with low back pain but is...
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Removal of discal cyst using percutaneous full endoscopic via interlaminar route: a case report
BackgroundDiscal cyst, a rare disease with unclear pathogenesis, exhibits symptoms similar to lumbar disk herniation. Currently, there is no...
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Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice
The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular...
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Serum antioxidant enzymes in spinal stenosis patients with lumbar disc herniation: correlation with degeneration severity and spinal fusion rate
ObjectiveTo determine whether superoxide dismutase (SOD) and glutathione reductase (GR) correlated with the intervertebral disc degeneration (IDD)...
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Terminal complement complex formation is associated with intervertebral disc degeneration
PurposeThe complement system is a crucial part of innate immunity. Recent work demonstrated an unexpected contribution to tissue homeostasis and...
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Effect of species, concentration and volume of local anesthetics on intervertebral disk degeneration in rats with discoblock
PurposeDiscoblock is effective in relieving discogenic low back pain, but it can also cause intervertebral disk degeneration (IDD). The effect of...
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Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis
Since the original description of spondyloarthritis 50 years ago, results have demonstrated similarities and differences between ankylosing...
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A new immunometabolic perspective of intervertebral disc degeneration
Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases in prevalence with age. IVD degeneration is a frequent...
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Preliminary exploration of the biomechanical properties of three novel cervical porous fusion cages using a finite element study
BackgroundPorous cages are considered a promising alternative to high-density cages because their interconnectivity favours bony ingrowth and...
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Effect of endplate reduction on endplate healing morphology and intervertebral disc degeneration in patients with thoracolumbar vertebral fracture
ObjectiveTo determine the effect of endplate reduction on the final healing morphology and degenerative changes in intervertebral discs.
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Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration
BackgroundIntervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular...
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Low back pain scores correlate with the cytokine mRNA level in lumbar disc biopsies: a study of inflammatory markers in patients undergoing lumbar spinal fusion
PurposeThe molecular mechanism behind pain in degenerative disc disease (DDD) and chronic low back pain (LBP) patients is largely unknown. This...
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Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase
BackgroundIntradiscal condoliase injection is an alternative therapeutic option for lumbar disc herniation (LDH). However, it is often associated...
