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Progress of Mitochondrial Function Regulation in Cardiac Regeneration
Heart failure and myocardial infarction, global health concerns, stem from limited cardiac regeneration post-injury. Myocardial infarction, typically...
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Metabolism-secretion coupling in glucose-stimulated insulin secretion
Pancreatic β-cells in the islets of Langerhans secrete insulin in response to blood glucose levels. Precise control of the amount of insulin secreted...
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Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging
Purpose of ReviewThe purpose of this review is to summarize the recently published scientific literature regarding the effects of mitochondrial...
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IDH2 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in multiple myeloma
Epigenetic alterations have been previously shown to contribute to multiple myeloma (MM) pathogenesis via DNA methylations and histone modifications....
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Glutamine stabilizes myc via alpha-ketoglutarate and regulates paclitaxel sensitivity
Metabolic reprogramming wherein the cancer cells exhibit altered energetics is a hallmark of cancer. Although recent discoveries have enhanced our...
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Pharmacokinetics/pharmacodynamics of ivosidenib in advanced IDH1-mutant cholangiocarcinoma: findings from the phase III ClarIDHy study
PurposeReport pharmacokinetic (PK)/pharmacodynamic (PD) findings from the phase III ClarIDHy study and any association between PK/PD parameters and...
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TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity
The heterogeneity and drug resistance of colorectal cancer (CRC) often lead to treatment failure. Isocitrate dehydrogenase 1 (IDH1), a rate-limiting...
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Therapies for IDH-Mutant Gliomas
Purpose of ReviewIsocitrate dehydrogenase ( IDH ) mutant gliomas are a distinct type of primary brain tumors with unique characteristics, behavior,...
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Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in the world. The emerging field of cardio-oncology has...
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Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
Undernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic...
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Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
Isocitrate dehydrogenase (IDH) mutations are found in 20% of acute myeloid leukemia (AML) patients. However, only 30–40% of the patients respond to...
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Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Seizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease....
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Changes of energy metabolism in failing heart and its regulation by SIRT3
Heart failure (HF) is the leading cause of hospitalization in elderly patients and a disease with extremely high morbidity and mortality rate...
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Mitochondrial Damage and Hypertension: Another Dark Side of Sodium Excess
Purpose of ReviewEssential or primary hypertension (HT) is a worldwide health problem with no definitive cure. Although the exact pathogenesis of HT...
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Differential expression of the BCAT isoforms between breast cancer subtypes
BackgroundBiological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have...
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GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis
Glutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated in tumor tissues of...
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