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Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients
Purpose Estrogen exposure is involved in both breast cancer susceptibility and the prognosis in patients with breast cancer. Aromatase is involved in...
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Current Understanding of Risk Factors for Ovarian Cancer
Ovarian cancer is the deadliest gynecologic cancer. Unlike many cancers such as breast, cervical and colon cancers, there is no easily clinically...
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A case of Antley-Bixler syndrome caused by compound heterozygous mutations of the cytochrome P450 oxidoreductase gene
Antley-Bixler syndrome (ABS) is a skeletal malformation syndrome primarily affecting the skull and limbs. Although causal mutations in the FGFR2 gene...
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Molecular biology of androgen-independent prostate cancer: the role of the androgen receptor pathway
Prostate cancer (PC) cells express the androgen receptor (AR) and need the presence of androgens to survive. Androgen suppression is the gold...
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GAB2 gene does not modify the risk of Alzheimer’s disease in Spanish APOE 4 carriers
ObjectivesThe genetic basis of Alzheimer’s disease (AD) is being analyzed in multiple whole genome association studies (WGAS). The GAB2 gene has been...
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Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production
BackgroundP450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes. Its deficiency causes Antley-Bixler syndrome (ABS), and...
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Profiling Gene Expression in Human Placentae of Different Gestational Ages: An OPRU Network and UW SCOR Study
We used the whole-genome approach to identify major functional categories of genes whose expression depends on gestational age. Using microarray...
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Association of genetic polymorphisms of ER-α and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women
Estrogen plays a role in breast cancer development, and genetic polymorphisms in estrogen receptor gene ER-α and genes regulating estrogen...
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CYP2C19*17 is associated with decreased breast cancer risk
Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism of xenobiotics and drugs and contributes to the catabolism of endogenous...
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The basic biochemistry and molecular events of hormone therapy
Data regarding the molecular response of prostate cancer to hormone therapy continue to emerge, identifying a complex network of autocrine and...
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Initial leukemic gene expression profiles of patients with poor in vivo prednisone response are similar to those of blasts persisting under prednisone treatment in childhood acute lymphoblastic leukemia
Response to initial glucocorticoid (GC) treatment is a strong prognostic factor in childhood acute lymphoblastic leukemia (ALL). Patients with a poor...
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Characterisation of aromatase expression in the human adipocyte cell line SGBS
Aromatase is a member of the cytochrome P450 superfamily of enzymes which catalyses the rate-limiting step in the biosynthesis of estrogens. A number...
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Transcriptional profiles of progestogen effects in the postmenopausal breast
Estrogen plus progestin hormone therapy has been associated with increased breast proliferation, breast density, and breast cancer risk in...
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Breast cancer: a candidate gene approach across the estrogen metabolic pathway
Polymorphisms within the estrogen metabolic pathway are prime candidates for a possible association with breast cancer risk. We investigated 11 genes...
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P450 oxidoreductase deficiency and Antley–Bixler syndrome
Antley–Bixler syndrome is a congenital malformation syndrome that primarily manifests with craniofacial abnormalities but may include skeletal...
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Basic concepts and recent developments in human steroid hormone biosynthesis
The biosynthesis of steroid hormones requires the coordinated expression of the enzymes that comprise the pathways via which specific hormones are...
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A Digenic Combination of Polymorphisms Within ESR1 and ESR2 Genes Are Associated With Age at Menarche in the Spanish Population
In the present study, the authors look at an association of genetic variants within estrogen synthesis and signaling pathways and age at menarche...