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Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development
BackgroundAdiponectin is an adipokine, mainly produced by adipose tissue. It regulates several reproductive processes. The protein expression of the...
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Sex determination and disorders of sex development according to the revised nomenclature and classification in 46,XX individuals
There have been considerable advances concerning understanding of the early and later stages of ovarian development; a number of genes have been...
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BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms
Polymorphisms in genes involved in DNA repair, steroid hormone biosynthesis/metabolism/signaling, folate metabolism as well as cell growth are prime...
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Polymorphisms in estrogen metabolism and estrogen pathway genes and the risk of miscarriage
PurposeThis study investigated genetic variations in the estrogen pathway and their association with miscarriages.
MethodsA total of 483 patients...
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Pubertal exposure to high fat diet causes mouse strain-dependent alterations in mammary gland development and estrogen responsiveness
Objective:Increased adolescent obesity rates in the United States are a significant public health concern. Obesity or increased adiposity during...
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Association between arterial stiffness and variations in oestrogen-related genes
Increased arterial stiffness and wave reflection have been identified as cardiovascular disease risk factors. In light of significant sex differences...
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The role of pharmacogenetics in selection of breast cancer treatment
Tumor characteristics have traditionally played a predominant role in adjuvant therapy recommendations for women with breast cancer. The role of host...
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Effects of body weight and alcohol consumption on insulin sensitivity
BackgroundObesity is a risk factor for the development of insulin resistance, which can eventually lead to type-2 diabetes. Alcohol consumption is a...
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Postmenopausal estrogen monotherapy–associated breast cancer risk is modified by CYP17A1_-34_T>C polymorphism
Long-term hormone therapy (HT) is a recognized risk factor for postmenopausal breast cancer. Elevated steroid hormone levels play a critical role in...
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Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells
The human aromatase gene ( CYP19A1 ) is controlled by multiple promoters that give rise to different aromatase transcripts. Its regulation has been...
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Estrogens as regulators of bone health in men
Bone metabolism is influenced by sex steroids during growth and adulthood in both men and women. Although this influence is well described in women,...
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Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action
BackgroundGarlic or Allium sativum (As) shows therapeutic effects such as reduction of blood pressure or hypercholesterolemia but side-effects on...
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Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants
ObjectiveTo study pathophysiologic pathways in spontaneous preterm birth and possibly the racial disparity associating with maternal and fetal...
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ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole
Endothelin-1 (ET-1) and endothelin A receptor (ETAR) contribute to the development and progression of breast carcinomas by modulating cell...
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Pharmacogenomics of Osteoporosis
Pharmacogenomics and pharmacogenetics are emerging interdisciplinary areas recently defined, respectively as “the investigation of variations of DNA...
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Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists
Ionizing radiation-associated breast cancer risk appears to be modified by timing of reproductive events such as age at radiation exposure, parity,...
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The Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs
MicroRNAs (miRNAs) which regulate gene expression stability displayed an aberrant expression profile in ectopic endometrium (ECE) as compared to...
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Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions
BackgroundSeveral cases of myopathies have been observed in the horse Norman Cob breed. Muscle histology examinations revealed that some families...
