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The potential therapeutic effect of klotho on cell viability in human colorectal adenocarcinoma HT-29 cells
Klotho is an anti-aging, anti-inflammator, and anti-oxidative protein and has been shown to important role in tumorigenesis, proliferation, survival,...
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Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus
BackgroundCompelling evidence suggests that the fibroblast growth factor 23 (FGF23) / α-klotho axis is impaired in subjects with diabetes mellitus....
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Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study
PurposeTestosterone plays a crucial role in males, and the deficiency of testosterone leads to multiple adverse health conditions. Klotho is a...
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Association between Dietary Inflammatory Index and serum Klotho concentration among adults in the United States
BackgroundKlotho is a hormone that emerges as an antiaging biomarker. However, the influence of the dietary pattern’s inflammatory potential on serum...
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Association of KLOTHO gene variants with metabolic and renal function parameters in Mexican patients living with type 2 diabetes
ObjectiveType 2 diabetes (T2D) and high blood pressure are the main causes of chronic kidney disease (CKD) in adulthood. Both metabolic and oxidative...
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The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population
BackgroundKlotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have...
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BMSC-derived exosomes protect against kidney injury through regulating klotho in 5/6 nephrectomy rats
AimThe aim of this study was to investigate the renoprotective effects of exosomes derived from rat bone marrow mesenchymal stem cells (rBMSCs) in a...
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Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is the major cause of kidney failure, and glomerular podocytes play critical roles in the pathogenesis of DN by...
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Life extension factor klotho regulates behavioral responses to stress via modulation of GluN2B function in the nucleus accumbens
Klotho is a life extension factor that has the ability to regulate the function of GluN2B-containing N-methyl- d -aspartate receptors (NMDARs), whose...
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Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair
Maxillofacial bone defects are commonly seen in clinical practice. A clearer understanding of the regulatory network directing maxillofacial bone...
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The association between serum soluble klotho levels and abdominal aorta calcification in older adults
BackgroundThe mutation of the mouse klotho gene leads to a syndrome resembling aging including calcification of the aorta.
ObjectiveTo examine the...
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Soluble α-Klotho levels, glycemic control and renal function in US adults with type 2 diabetes
AimsSoluble Klotho (s-Klotho) is associated with chronic kidney disease (CKD) and aging, but little is known on its relationship with chronic micro-...
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Association between environmental exposure to perchlorate, nitrate, and thiocyanate and serum α-Klotho levels among adults from the National Health and nutrition examination survey (2007–2014)
Background & aimsAging is a pathophysiological process driven by a diverse set of complex biological processes, and environmental pollution plays an...
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Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study
BackgroundThe ageing process can be influenced by energy intake and different macronutrients within the diet. The soluble form of the a-Klotho gene...
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Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes cartilage and bone damage as well as disability.
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BDNF, GDNF, NGF and Klotho levels and neurocognitive functions in acute term of schizophrenia
BackgroundKlotho and its relationship with neurotrophic factors and cognition in schizophrenia has not yet been investigated. In this study, the...
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Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension
BackgroundHypertension and diabetes are among the most important risk factors of cardiovascular diseases. Klotho and SIRT1 are known as anti-aging...
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Post-kidney transplant soluble Klotho levels are determined by pretransplant soluble Klotho levels in both living donors and recipients
BackgroundSoluble Klotho (sKl), the free form of membrane-bound Klotho predominantly expressed in the kidney, is detectable in serum and may have...
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The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23
BackgroundChronic kidney disease (CKD) is associated with increased propensity for arrhythmias. In this context, ventricular repolarization...
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Relationship between serum fibroblast growth factor 19 and vascular endothelial growth factor and soluble klotho protein in type 1 diabetic children
BackgroundFibroblast growth factor 19 (FGF19) takes part in maintaining the balance of glycolipids and may be involved in complications of type 1...
