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The role of automated insulin delivery technology in diabetes
The role of automated insulin delivery systems in diabetes is expanding. Hybrid closed-loop systems are being used in routine clinical practice for...
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Transplant strategies for type 1 diabetes: whole pancreas, islet and porcine beta cell therapies
Whole-organ pancreas and islet transplantations are performed in a highly selected group of patients with diabetes mellitus, primarily those with...
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ARISE—a prospective, non-interventional, single-arm study assessing clinical parameters associated with the use of insulin degludec/insulin aspart in patients with type 2 diabetes in real-world settings: rationale and design
PurposeIDegAsp, a co-formulation of long-acting basal (insulin degludec) and rapid-acting bolus (insulin aspart) insulin, provides separate prandial...
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Expert Opinion on Current Trends in the Use of Insulin in the Management of People with Type 2 Diabetes from the South-Eastern European Region and Israel
Despite the availability of various antihyperglycaemic therapies and comprehensive guidelines, glycaemic control in diabetes management has not...
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Cognitive Frailty in Older People with Type 2 Diabetes Mellitus: the Central Role of Hypoglycaemia and the Need for Prevention
Purpose of ReviewTo highlight the central role of hypoglycaemia in the causation of cognitive frailty and explore ways of recognition and prevention...
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Diabetes and Frailty: An Expert Consensus Statement on the Management of Older Adults with Type 2 Diabetes
Prognosis and appropriate treatment goals for older adults with diabetes vary greatly according to frailty. It is now recognised that changes may be...
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Impact of Age on the Effectiveness and Safety of Insulin Glargine 300 U/mL: Results from the REALI European Pooled Data Analysis
IntroductionPatients aged ≥ 65 years continue to be underrepresented in clinical studies related to type 2 diabetes mellitus (T2DM). Accordingly, the...
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Type 2 diabetes mellitus in older adults: clinical considerations and management
The past 50 years have seen a growing ageing population with an increasing prevalence of type 2 diabetes mellitus (T2DM); now, nearly half of all...
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Usefulness of the Hypoglycemia awareness questionnaire in characterizing the Hypoglycemia events, proactive behaviors, and healthcare services used in patients with type 2 diabetes treated with insulin
ObjectiveHypoglycemia is a serious complication of type 2 diabetes (DM2), but its severity and incidence and the healthcare services used are usually...
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The emergence of obesity in type 1 diabetes
Obesity, a chronic low-grade inflammatory disease represented by multifactorial metabolic dysfunctions, is a significant global health threat for...
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Real-World Effectiveness and Safety of Insulin Glargine 300 U/mL in Patients with T2D Uncontrolled on NPH or Premixed Insulins as Part of Routine Clinical Practice in Bulgaria: ToUPGRADE Study
IntroductionThe aim of this study is to demonstrate the real-life effectiveness and safety of insulin glargine 300 U/mL (Gla-300) in patients with...
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Adjusting the Use of Glucose-Lowering Agents in the Real-World Clinical Management of People with Type 2 Diabetes: A Narrative Review
Despite the availability of new treatment classes, glycaemic control in patients with diabetes remains suboptimal globally. The latter is associated...
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Gender differences in quality of life in adults with long-standing type 1 diabetes mellitus
BackgroundTo assess gender differences in Quality of life (QoL) and in sociodemographic, clinical and psychological factors associated with impaired...
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Hypothalamic glucose-sensing mechanisms
Chronic metabolic diseases, including diabetes and obesity, have become a major global health threat of the twenty-first century. Maintaining glucose...
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Modern Management of Cardiometabolic Continuum: From Overweight/Obesity to Prediabetes/Type 2 Diabetes Mellitus. Recommendations from the Eastern and Southern Europe Diabetes and Obesity Expert Group
The increasing global incidence of obesity and type 2 diabetes mellitus (T2D) underscores the urgency of addressing these interconnected health...
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Breastfeeding at night is rarely followed by hypoglycaemia in women with type 1 diabetes using carbohydrate counting and flexible insulin therapy
Aims/hypothesisHypoglycaemia in association with breastfeeding is a feared condition in mothers with type 1 diabetes. Thus, routine carbohydrate...
