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Identification of hub genes in rheumatoid arthritis through an integrated bioinformatics approach
BackgroundRheumatoid arthritis (RA) is a common chronic autoimmune disease characterized by inflammation of the synovial membrane. However, the...
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Pathology of pain and its implications for therapeutic interventions
Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is...
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Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers
Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through...
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Non-coding RNAs in ossification of spinal ligament
PurposeOssification of the spinal ligament (OSL) is a disease characterized by progressive ectopic ossification or calcification in the tissues of...
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Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases
Metabolic function and energy production in eukaryotic cells are regulated by mitochondria, which have been recognized as the intracellular...
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Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review
Intervertebral disc degeneration (IDD) is the most common cause of low-back pain. Accumulating evidence indicates that the expression profiling of...
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Signaling pathways and targeted therapy for myocardial infarction
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a worldwide disease with high morbidity and high...
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Alternative splicing and related RNA binding proteins in human health and disease
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein...
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RNA-binding proteins and their role in kidney disease
RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene regulation and protein synthesis. They are required for...
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RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis
BackgroundCircular RNAs (circRNAs) are increasingly recognized as important regulators in cancer including ovarian cancer (OC). This work focuses on...
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Posttranslational Modifications: Emerging Prospects for Cardiac Regeneration Therapy
Heart failure (HF) following ischemic heart disease (IHD) remains a hard nut to crack and a leading cause of death worldwide. Cardiac regeneration...
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Circular RNAs as important players in human gastric cancer
As one of the most prevalent gastrointestinal diseases, gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. Since GC...
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Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks
BackgroundThe traditional Chinese medicine prescription, Qianggan formula have been confirmed to be effective on non-alcoholic steatohepatitis...
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