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Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting a unique capacity to self-renew and differentiate into...
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Oncogenic dependency on SWI/SNF chromatin remodeling factors in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy arising from immature thymocytes. Unlike well-known oncogenic transcription...
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tiRNA-Val-CAC-2 interacts with FUBP1 to promote pancreatic cancer metastasis by activating c‑MYC transcription
Cumulative studies have established the significance of transfer RNA-derived small RNA (tsRNA) in tumorigenesis and progression. Nevertheless, its...
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A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription
The essential G 1 -cyclin, CCND1 , is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type...
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Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
BackgroundAdministration of propofol, an intravenous anesthetic with antioxidant property, immediately at the onset of post-ischemic reperfusion...
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Molecular Subtypes of Extra-pulmonary Neuroendocrine Carcinomas Identified by the Expression of Neuroendocrine Lineage-Specific Transcription Factors
Extra-pulmonary neuroendocrine carcinomas (EPNEC) represent a group of rare and heterogenous neoplasms with adverse clinical outcome. Their molecular...
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Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy in North America. Current therapeutic regimens are ineffective against...
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Expression of mitochondrial transcription factor A in granulosa cells: implications for oocyte maturation and in vitro fertilization outcomes
ObjectiveIn vitro fertilization-embryo transfer (IVF-ET) is a widely used treatment for infertility, with oocyte maturation and quality having a...
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EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells
BackgroundPost-transcriptional regulation plays a critical role in controlling biological processes such as aging. Previous studies have shown that...
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Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes
Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor that is implicated in a variety of psychiatric disorders including...
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Transcription factor c-fos induces the development of premature ovarian insufficiency by regulating MALAT1/miR-22-3p/STAT1 network
BackgroundThe current study attempted to investigate the role of transcription factor c-fos in the development of premature ovarian insufficiency...
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Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma
PurposeGrowth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like...
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Identification of transcription factors and construction of a novel miRNA regulatory network in primary osteoarthritis by integrated analysis
BackgroundsAs osteoarthritis (OA) disease-modifying therapies are not available, novel therapeutic targets need to be discovered and prioritized....
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Immunological and Non-Immunological Risk Factors in Anaphylaxis
Purpose of ReviewAnaphylaxis can lead to fatal reactions, the causes of which are very diverse and whose triggers may not always be identifiable....
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Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL
T lymphocyte acute lymphoblastic leukemia (T-ALL) is frequently associated with increased expression of the E protein transcription factor inhibitors...
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Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, the transcription factor...
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Thyroid transcription factor‐1 expression in lung neuroendocrine tumours: a gender-related biomarker?
PurposeThyroid transcription factor‐1 (TTF‐1) assessed by immunohistochemistry (IHC) is a specific biomarker for lung adenocarcinoma, and is commonly...
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Transcription factor SOX3 upregulated pro-apoptotic genes expression in human breast cancer
BackgroundSex-determining region Y-box 3 (SOX3) protein, a SOX transcriptions factors group, has been identified as a key regulator in several...
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Transcription associated cyclin-dependent kinases as therapeutic targets for prostate cancer
Transcriptional deregulation has emerged as a hallmark of several cancer types. In metastatic castration-resistant prostate cancer, a stage in which...
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A clinicoradiological analysis of silent corticotroph adenomas after the introduction of pituitary-specific transcription factors
BackgroundSilent corticotroph adenomas (SCAs) are a rare subtype of non-functional pituitary adenoma. While it has been suggested that they are more...
