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Perspectives from the Society for Pediatric Research: pharmacogenetics for pediatricians
AbstractThis review evaluates the pediatric evidence for pharmacogenetic associations for drugs that are commonly prescribed by or encountered by...
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Inflammatory bowel disease in pregnancy and breastfeeding
Inflammatory bowel disease (IBD) has a peak age of diagnosis before the age of 35 years. Concerns about infertility, adverse pregnancy outcomes, and...
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Mycosis fungoides in a patient with ulcerative colitis on anti-tumor necrosis factor-alpha therapy
A 46-year-old man with a history of ulcerative colitis (UC) for over 25 years was treated with infliximab for 7 years. He noticed gradually spreading...
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Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria
BackgroundHospitalization for ulcerative colitis (UC) is potentially life-threatening. Severe disease in the Japanese criteria which modifies the...
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High Rates of Seroprotection to Hepatitis B After a Hepatitis B Challenge Dose in Previously Vaccinated Patients with Inflammatory Bowel Disease on Immunosuppressive Therapy
BackgroundHealthy populations have high rates of sustained vaccine-induced seroprotection to hepatitis B virus, but previous studies in...
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A review article of inflammatory bowel disease treatment and pharmacogenomics
Inflammatory bowel disease (IBD) involves a variety of conditions, particularly Crohn’s disease (CD) and ulcerative colitis (UC). IBD is...
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Reactive Immunomodulator Addition to Infliximab Monotherapy Restores Clinical Response in Inflammatory Bowel Disease: A Meta-Analysis
Background and AimsPatients with inflammatory bowel disease (IBD) receiving infliximab (IFX) commonly experience immunogenic loss of response (LOR)...
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Low-Dose Azathioprine in Combination with Allopurinol: The Past, Present and Future of This Useful Duo
The inflammatory bowel diseases (IBD) are complex immune-mediated inflammatory diseases that are associated with significant morbidity around the...
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Conception, pregnancy and inflammatory bowel disease—Current concepts for the practising clinician
The peak incidence of inflammatory bowel disease (IBD) coincides with a woman’s prime reproductive years. The management of IBD during pregnancy can...
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Maintenance Treatment in Acute Lymphoblastic Leukemia: A Clinical Primer
Cure rates in pediatric acute lymphoblastic leukemia (ALL) currently approach 90% in the developed world. Treatment involves 6-8 mo of intensive...
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Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia
Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal...
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Comprehensive review and update of stricturing Crohn’s disease
Up to 50% of patients with Crohn’s disease develop a stricture within 10 years of diagnosis. Crohn’s strictures can compose of inflammation, fibrosis...
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Efficacy, safety and drug survival of thioguanine as maintenance treatment for inflammatory bowel disease: a retrospective multi-centre study in the United Kingdom
BackgroundThioguanine (TG) is a thiopurine which has been used for patients with inflammatory bowel disease (IBD), who have failed azathioprine (AZA)...
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The Management of Postoperative Recurrence in Crohn’s Disease
Purpose of ReviewAlthough the need for intestinal resection as a treatment for Crohn’s disease (CD) has significantly decreased as the use of...
