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Nonlesional epilepsy—a case report in adult epileptology
We report the case of a patient with nonlesional, pharmacoresistant epilepsy. Bilateral synchronous discharges as well as focal discharges were...
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Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer’s disease
PurposeTo investigate the temporal trajectories of tau and amyloid-β (Aβ) accumulation in Alzheimer’s disease (AD) by using the longitudinal positron...
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Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing
PurposeTo evaluate the diagnostic accuracy of epilepsy-dedicated 3 Tesla MRI including post-processing by correlating MRI, histopathology, and...
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Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up pattern
Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer’s disease, closely related to cognitive dysfunction and...
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Dynamic-related protein 1 inhibitor eases epileptic seizures and can regulate equilibrative nucleoside transporter 1 expression
BackgroundDynamic-related protein 1 (Drp1) is a key protein involved in the regulation of mitochondrial fission, and it could affect the dynamic...
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Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning
Stress exposure impairs brain structure and function, resulting in cognitive deficits and increased risk for psychiatric disorders such as...
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Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
GABAergic inhibition plays an important role in the establishment and maintenance of cortical circuits during development. Neuregulin 1 (Nrg1) and...
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Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database
TDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal lobar degeneration (FTLD-TDP), in amyotrophic lateral...
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The GABAA receptor modulator zolpidem augments hippocampal-prefrontal coupling during non-REM sleep
Benzodiazepines and ‘Z-drugs’ (including zolpidem and zopiclone) are GABA A receptor (GABA A R) positive modulators commonly prescribed as hypnotics to...
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Toxic leukoencephalopathy with axonal spheroids caused by chemotherapeutic drugs other than methotrexate
BackgroundThe objective of this report is to share the clinicopathological features of chemotherapy-induced toxic leukoencephalopathy, which is a...
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Frontotemporal neurofibrillary tangles and cerebrovascular lesions are associated with autism spectrum behaviors in late-life dementia
Background and objectivesThe pathologic substrates or neuroanatomic regions responsible for similarities in behavioral features seen in autism...
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Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling
Childhood maltreatment (CM) has been associated with changes in structural brain connectivity even in the absence of mental illness. Social support,...
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Brain structural changes in preschool children with MRI-negative epilepsy
PurposeTo investigate abnormalities in cortical and subcortical structures of the brain in preschool children with MRI-negative epilepsy.
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Descriptive and functional anatomy of the Heschl Gyrus: historical review, manual labelling and current perspectives
PurposeThe Heschl Gyrus (HG), which includes the Primary Auditory Cortex (PAC), lies on the upper surface of the superior temporal gyrus (T1). It has...
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Comparison of quantitative FDG-PET and MRI in anti-LGI1 autoimmune encephalitis
ObjectivesAnti-leucine glioma-inactivated protein 1 (anti-LGI1) autoimmune encephalitis (AE) presents as subacute memory loss, behavioral changes,...
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Burr hole microsurgical subtemporal selective amygdalohippocampectomy
IntroductionAt present, selective amygdalohippocampectomy (SAH) has become popular in the treatment of drug-resistant mesial temporal lobe epilepsy...
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Lewy body disease as a potential negative outcome modifier of glioblastoma treatment: a case report
BackgroundElderly patients with glioblastoma are particularly susceptible to the adverse effects of ionizing radiation to the brain. This population...
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Is Alzheimer disease a disease?
Dementia, a prevalent condition among older individuals, has profound societal implications. Extensive research has resulted in no cure for what is...
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Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G
Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant...
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Age-, sex-, and pathology-related variability in brain structure and cognition
This work aimed to investigate potential pathways linking age and imaging measures to early age- and pathology-related changes in cognition. We used...
