Search
Search Results
-
Glycyrrhizin Ameliorates Cardiac Injury in Rats with Severe Acute Pancreatitis by Inhibiting Ferroptosis via the Keap1/Nrf2/HO-1 Pathway
BackgroundSevere acute pancreatitis (SAP) is a potential fatal gastrointestinal disease that is usually complicated by myocardial injury and...
-
Myco-synthesized copper oxide nanoparticles using harnessing metabolites of endophytic fungal strain Aspergillus terreus: an insight into antibacterial, anti-Candida, biocompatibility, anticancer, and antioxidant activities
BackgroundThe overuse of antibiotics leads to the emergence of antibiotic-resistant microbes which causes high mortality worldwide. Therefore, the...
-
Evaluation of in vitro anthelmintic activity of crude extract and synthesized green silver nanoparticles of the leaves of Mammea americana L.
One of the most severe parasite infections to ever plague animals, paramphistomosis is particularly devastating in tropical and subtropical areas and...
-
Investigation of the potential role of TGR5 in pancreatic cancer by a comprehensive molecular experiments and the liquid chromatography mass spectrometry (LC–MS) based metabolomics
BackgroundTakeda G protein receptor 5 (TGR5) is widely recognized as a potential drug target for the treatment of metabolic diseases. TGR5 is not...
-
Homozygous SPAG6 variants can induce nonsyndromic asthenoteratozoospermia with severe MMAF
BackgroundMultiple morphological abnormalities of the sperm flagella (MMAF) is a subtype of severe asthenoteratozoospermia with poorly understood...
-
A DoE-based development and characterization of Nadifloxacin-loaded transethosomal gel for the treatment of Acne vulgaris
BackgroundThe objective of this current research was to enhance the topical delivery of Nadifloxacin (NDFX) by incorporating it into a transethosomal...
-
Natural approach of using nisin and its nanoform as food bio-preservatives against methicillin resistant Staphylococcus aureus and E.coli O157:H7 in yoghurt
BackgroundNatural antimicrobial agents such as nisin were used to control the growth of foodborne pathogens in dairy products. The current study...
-
Morphological characterization and clinical effects of stromal alterations after intracorneal ring segment implantation in keratoconus
PurposeTo analyze the histological and (ultra)structural stromal tissue changes after femtosecond (Fs) laser–assisted intracorneal ring segment...
-
Preoperative chemoradiotherapy affects postoperative outcomes and functional results in patients treated with transanal endoscopic microsurgery for rectal neoplasms
BackgroundThe aim of this study was to quantify the incidence of short-term postoperative complications and functional disorders at 1 year from...
-
Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation
BackgroundGouty arthritis is the most frequently diagnosed inflammatory arthritis worldwide. Dynamin-related protein 1 (Drp1), a regulator of...
-
Bufalin Induces Programmed Necroptosis in Triple-Negative Breast Cancer Drug-Resistant Cell Lines through RIP1/ROS-Mediated Pathway
ObjectiveTo explore the effect and mechanism of action of bufalin in triple-negative breast cancer (TNBC) drug-resistant cell lines.
Methods ... -
A Cholecystokinin Analogue Ameliorates Cognitive Deficits and Regulates Mitochondrial Dynamics via the AMPK/Drp1 Pathway in APP/PS1 Mice
BackgroundThere are no drugs on the market that can reverse or slow Alzheimer’s disease (AD) progression. A protease-resistant Cholecystokinin (CCK)...
-
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway
PurposeOsteoarthritis (OA) is a common joint disease characterized by cartilage degeneration, synovial inflammation, osteophytes, and subchondral...
-
Corneal epithelial ingrowth after perforating corneal injury: a case report
BackgroundEpithelial ingrowth is a rare complication after ocular perforation and can become manifest many years after the primary trauma.
...
-
BNIP3-mediated autophagy via the mTOR/ULK1 pathway induces primordial follicle loss after ovarian tissue transplantation
PurposeTo explore the underlying mechanism of primordial follicle loss in the early period following ovarian tissue transplantation (OTT).
...
-
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer
BackgroundAs the increasing mortality and incidence of lung cancer (LC), there is an urgent need to discover novel treatment agent. In this study, we...
-
Phytoconstituent analysis, anti-inflammatory, antimicrobial and anticancer effects of nano encapsulated Convolvulus arvensis L. extracts
BackgroundThe Convolvulus genus is distributed all over the world and has a long history in traditional medicine. As nanotechnology expands its...
-
Gentiopicroside inhibits the progression of gastric cancer through modulating EGFR/PI3K/AKT signaling pathway
BackgroundThis study was designed to clarify the function and potential mechanism of gentiopicroside (GPS) in regulating the malignant progression of...
-
Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice
Aims/hypothesisDiabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction,...
-
Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs
BackgroundZedoary turmeric oil extracted from the roots of curcuma ( Curcuma aeruginosa Roxb.) is used for the treatment of myocarditis in China....
