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Altered gut microbiota–host bile acid metabolism in IBS-D patients with liver depression and spleen deficiency pattern
BackgroundDysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel...
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Predicting response to non-selective beta-blockers with liver–spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices
IntroductionNon-selective beta-blockers (NSBB) are used for primary prophylaxis in patients with liver cirrhosis and high-risk varices (HRVs)....
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Ultrasonic spleen thickness-based indexes surpass Baveno VI criteria in high-risk gastroesophageal varices detection
AimsTo evaluate the efficiency of ultrasonic spleen thickness (UST), routine variables and (expanded) Baveno VI criteria for high-risk...
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Morphometric assessment of spleen dimensions and its determinants among individuals living in Arba Minch town, southern Ethiopia
IntroductionThe spleen is a vital lymphoid soft organ that demands constant attention from the clinical point of view. It is a multi-dimensional...
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Differentiation of insulinoma from accessory spleen by 99mTc-labelled heat-denaturated red blood cell scintigraphy: case report
BackgroundNeuroendocrine tumors (NETs) are rare tumors harboring overexpression of somatostatin receptors (SSTRs) on their cell membrane. Because...
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Refractory hepatosplenic T-cell lymphoma was successfully treated with salvage allogeneic hematopoietic stem cell transplantation combined with enhanced myeloablative preconditioning
This study aims to evaluate the clinical benefit of salvage allogeneic hematopoietic stem cell transplantation (allo-HSCT) in combination with...
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Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion
There is evidence that the orphan nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in exhausted CD8 + T cells and regulates PD-L1 in tumors. This...
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Contrast-enhanced ultrasound of the spleen, pancreas and gallbladder in children
Gray-scale and color/power Doppler ultrasound (US) are the first-line imaging modalities to evaluate the spleen, gallbladder and pancreas in...
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Investigation of spleen CXCR4 expression by [68Ga]Pentixafor PET in a cohort of 145 solid cancer patients
BackgroundThe chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid...
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Clinical observation of pediatric Tuina plus oral Chinese medication for pediatric anorexia due to spleen failing in transportation
ObjectiveTo observe the clinical efficacy of pediatric Tuina (Chinese therapeutic massage) plus oral administration of Chinese medication for...
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Acute Abdomen in Atrial Fibrillation Due to Thromboembolism of the Kidney and Spleen
Acute abdomen triggered by viscus arterial occlusion is a severe condition, often presenting remarkable abdominal pain but with mild abdominal signs...
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Gastrosplenic fistula due to diffuse large B-cell lymphoma: case report
BackgroundGastrosplenic fistula (GSF) is a rare complication of various benign and malignant etiologies. Splenic lymphoma is the most common cause of...
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Elevated spleen FDG uptake predicts unfavorable outcome in adult idiopathic-inflammatory-myopathy patients: a crisis beyond muscles
BackgroundIdiopathic inflammatory myopathy (IIM) is a group of autoimmune diseases that frequently leads to unfavorable outcome. This study aimed at...
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89Zr-leukocyte labelling for cell trafficking: in vitro and preclinical investigations
BackgroundThe non-invasive imaging of leukocyte trafficking to assess inflammatory areas and monitor immunotherapy is currently generating great...
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Percutaneous radiofrequency ablation of ovarian cancer metastasis in the spleen: a therapeutic option to consider
Splenic metastasis are rare clinical entities develo** in less than 1% of all metastatic cancers and usually in the setting of disseminated...
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Late Recurrence of Granulosa Cell Tumour Involving the Retroperitoneum and Spleen
Granulosa cell tumour of the ovary is a sex-cord stromal tumour that accounts for 2–5% of all ovarian neoplasms. It is a low-grade malignant tumour...
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Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia
Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy with a fulminant clinical course. Our previous study revealed that...
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Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate
Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Elucidating how pancreatic tumor-specific T cells...
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First reported case of splenic diffuse red pulp small B-cell lymphoma with novel mutations in CXCR4 and TRAF3 genes
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is a rare B-cell tumor whose genetic characteristics are poorly understood. Here, we introduce...
