Search
Search Results
-
Two cases of spindle cell tumors with S100 and CD34 co-expression showing novel RAF1 fusions
BackgroundRecently, a novel group of CD34 and S100 co-expression spindle cell tumors with distinctive stromal and perivascular hyalinization...
-
NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusion
NTRK -rearranged uterine sarcoma is a recently described entity that represents a subset of uterine sarcomas with distinct clinicopathological...
-
The N501Y Mutation of SARS-CoV-2 Spike Protein Impairs Spindle Assembly in Mouse Oocytes
The COVID-19 pandemic has been continuing for one and a half year and caused a profound effect on human health. Although advanced researches and...
-
-
ARID1A deficient undifferentiated spindle cell and rhabdoid sarcoma of the prostate: report of a unique case with emphasis on diagnostic implications
BackgroundSWItch Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex functions collectively as a tumor suppressor and the inactivation of...
-
-
Atypical thymomas with squamoid and spindle cell features: clinicopathologic, immunohistochemical and molecular genetic study of 120 cases with long-term follow-up
Thymomas are rare tumors characterized by a broad range of morphologic appearances that can sometimes give rise to difficulties for classification....
-
Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation
SMAD4 loss-of-function mutations have been frequently observed in colorectal cancer (CRC) and are recognized as a drug target for therapeutic...
-
Mucinous tubular and spindle cell carcinomas of the kidney (MTSCC-Ks): CT and MR imaging characteristics
PurposeTo strengthen the recognition of mucinous tubular and spindle cell carcinomas of the kidney (MTSCC-Ks) by analyzing CT and MR imaging findings...
-
Monopolar spindle 1 contributes to tamoxifen resistance in breast cancer through phosphorylation of estrogen receptor α
PurposeThe overexpression of mitotic kinase monopolar spindle 1 (Mps1) has been identified in many tumor types, and targeting Mps1 for tumor therapy...
-
RAF1-rearranged spindle cell tumour: report of two additional cases with identification of a novel FMR1-RAF1 fusion
A subset of spindle cell tumours have been recently identified to harbor recurrent fusion genes, involving NTRK1/2/3 , BRAF , RAF1 , and RET . The...
-
Deep-learning based classification distinguishes sarcomatoid malignant mesotheliomas from benign spindle cell mesothelial proliferations
Sarcomatoid mesothelioma is an aggressive malignancy that can be challenging to distinguish from benign spindle cell mesothelial proliferations based...
-
Surgical resection of a rapidly growing pulmonary spindle cell carcinoma by robot-assisted thoracoscopic surgery: a case report
BackgroundPulmonary spindle cell carcinoma (PSCC) is an extremely rare tumor that is highly malignant and fast-growing. As chemotherapy and radiation...
-
Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy
BackgroundContinuous spike and wave of sleep with encephalopathy (CSWS) is a rare and severe developmental electroclinical epileptic encephalopathy...
-
WAPL orchestrates porcine oocyte meiotic progression via control of spindle assembly checkpoint activity
BackgroundIn mitotic cells, WAPL acts as a cohesin release factor to remove cohesin complexes from chromosome arms during prophase to allow the...
-
Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements
NTRK -rearranged mesenchymal neoplasms mostly affect the soft tissues of pediatric patients. Given the responsiveness to selective NTRK inhibitors, it...
-
Spindle Cell Lipoma Arising from the Supraglottis: A Case Report and Review of the Literature
Lipomas are common benign mesenchymal neoplasms. Although 13% of lipomas are found in the head and neck, only 0.6% have been reported in the larynx....
-
Spindle Cell Hemangioma of Lower Lip: The Fourth Case Report with Review of Literature
BackgroundSpindle cell hemangioma previously known as spindle cell hemangioendothelioma is a benign vascular tumour with rare presentation in head...
-
Spindle Cell Squamous Cell Carcinoma of Head and Neck Region: a Clinicopathological and Immunohistochemical Study
Spindle cell squamous cell carcinoma (SCSCC) represents a rare, dedifferentiated form of conventional squamous cell carcinoma (SCC) with propensity...
-
Spindle Cell Carcinoma of Nasal Septum: A Rare Case Report with Review of Literature
Spindle Cell Carcinoma (SpCC) is a rare neoplasm that occurs mainly in the upper aero-digestive tract, mostly in larynx. We present a case of SpCC...
