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Drug Repurposing: Claiming the Full Benefit from Drug Development
Purpose of ReviewDrug development has evolved over the years from being one-at-a-time to be massive screens in an industrial manner. Bringing a new...
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Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
BackgroundThe presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance....
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Discovery and repurposing of artemisinin
Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional...
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Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing
Major depressive disorder (MDD) is the single largest contributor to global disability and up to 20–30% of patients do not respond to at least two...
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Repurposing pantoprazole in combination with systemic therapy in advanced head and neck squamous cell carcinoma: a phase I/II randomized study
Pantoprazole decreases the acidity of the tumor microenvironment by inhibiting proton pumps on the cancer cell. This possibly leads to increased...
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A drug repurposing study identifies novel FOXM1 inhibitors with in vitro activity against breast cancer cells
FOXM1, a proto-oncogenic transcription factor, plays a critical role in cancer development and treatment resistance in cancers, particularly in...
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Drug Repurposing in Medulloblastoma: Challenges and Recommendations
Medulloblastoma is the most frequently diagnosed primary malignant brain tumor among children. Currently available therapeutic strategies are based...
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Repurposing sodium-glucose co-transporter 2 inhibitors (SGLT2i) for cancer treatment – A Review
Developed as an antidiabetic drug, recent evidence suggests that several sodium-glucose co-transporter 2 inhibitors (SGLT2i), especially...
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Topiramate Utilization After Phentermine/Topiramate Approval for Obesity Management: Risk Minimization in the Era of Drug Repurposing
IntroductionThe US FDA required a Risk Evaluation and Mitigation Strategy (REMS) for phentermine/topiramate, an anti-obesity medication, to prevent...
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Integrated systems biology analysis of acute lymphoblastic leukemia: unveiling molecular signatures and drug repurposing opportunities
Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by aberrant proliferation and accumulation of lymphoid precursor cells...
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Drug repositioning and repurposing for Alzheimer disease
Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for...
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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Zika virus (ZIKV) is an emerging pathogen associated with neurological complications, such as Guillain-Barré syndrome in adults and microcephaly in...
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Challenges of repurposing tetracyclines for the treatment of Alzheimer’s and Parkinson’s disease
The novel antibiotic-exploiting strategy in the treatment of Alzheimer’s (AD) and Parkinson’s (PD) disease has emerged as a potential breakthrough in...
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Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma
Mesenchymal chondrosarcoma (MCS) is a high-grade malignancy that represents 2–9% of chondrosarcomas and mostly affects children and young adults....
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Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug...
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Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses
Morbidity and mortality from opioid use disorders (OUD) and other substance use disorders (SUD) is a major public health crisis, yet there are few...
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Signature-based approaches for informed drug repurposing: targeting CNS disorders
CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering therapeutics. The limited understanding of the mechanisms...
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Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma
Background Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly...
