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An ontology-based approach for modelling and querying Alzheimer’s disease data
BackgroundThe recent advances in biotechnology and computer science have led to an ever-increasing availability of public biomedical data distributed...
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Impact of Differential Rates of Disease Progression in Amyloid-Positive Early Alzheimer’s Disease: Findings from a Longitudinal Cohort Analysis
BackgroundThere is limited literature regarding the impact of differential rates of disease progression on longitudinal outcomes in individuals with...
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Digital Health Technologies for Alzheimer’s Disease and Related Dementias: Initial Results from a Landscape Analysis and Community Collaborative Effort
Digital health technologies offer valuable advantages to dementia researchers and clinicians as screening tools, diagnostic aids, and monitoring...
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Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with cognitive dysfunction as its major clinical symptom. However, there is no...
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Beyond Vision: A View from Eye to Alzheimer’s Disease and Dementia
With the aging of the global population, the health care burden of Alzheimer’s disease (AD) and dementia is considered to increase dramatically in...
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Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Because of the progressive neurodegeneration, individual cognitive and...
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A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer’s Disease
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct...
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Examining the Diagnostic Accuracy of a Novel Performance-Based Test for Alzheimer’s Disease Screening
Affordable, rapid methods for identifying mild Alzheimer’s disease (AD) are needed. A simple, brief performance-based test involving the learning of...
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XGBoost-SHAP-based interpretable diagnostic framework for alzheimer’s disease
BackgroundDue to the class imbalance issue faced when Alzheimer’s disease (AD) develops from normal cognition (NC) to mild cognitive impairment...
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Targeting the molecular web of Alzheimer’s disease: unveiling pathways for effective pharmacotherapy
IntroductionAlzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with...
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Cost of Patients with Alzheimer’s Disease in Spain According to Disease Severity
BackgroundAlzheimer’s disease (AD) has been associated with great healthcare and non-healthcare resource consumption. The aim of this study was to...
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Alzheimer’s Disease: Combination Therapies and Clinical Trials for Combination Therapy Development
Alzheimer’s disease (AD) is a complex multifaceted disease. Recently approved anti-amyloid monoclonal antibodies slow disease progression by...
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Akt signaling pathway: a potential therapy for Alzheimer’s disease through glycogen synthase kinase 3 beta inhibition
Alzheimer’s disease (AD) is a form of dementia marked by the accumulation of neuritic plaques and neurofibrillary tangles through the action of...
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Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer’s Disease Continuum
In the past years, neuroinflammation has been widely investigated in Alzheimer’s disease (AD). Evidence from animal, in vivo and post-mortem studies...
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Safety, Efficacy and Clinical Applications of Focused Ultrasound-Mediated Blood Brain Barrier Opening in Alzheimer’s Disease: A Systematic Review
Alzheimer’s disease is a neurodegenerative disorder marked by cognitive decline and brain pathology involving amyloid plaques and neurofibrillary...
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Donepezil-based combination therapy for Alzheimer’s disease and related neuropathies
Combination therapy has birthed improved treatment possibilities for a number of complex and degenerative diseases in the world, which include...
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Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease
Despite an ever-growing prevalence and increasing economic burden of Alzheimer’s disease (AD) and Parkinson’s disease (PD), recent advances in drug...
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Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials
Recent high-profile failures of Alzheimer disease treatments at the clinical trial stage have led to renewed efforts to identify and test novel...
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PET molecular imaging for pathophysiological visualization in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common dementia worldwide. The exact etiology of AD is unclear as yet, and no effective treatments are currently...
