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Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma
BackgroundMultiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with...
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Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction
ObjectivesExosomal Phospho-Tau-181(P-T181-tau), Total tau (T-tau), and amyloid-β peptide 42 (Aβ42) have been proved the capacity for the amnestic...
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Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections
BackgroundSelf-sampling of dried blood spots (DBS) offers new routes to gather valuable health-related information from the general population. Yet,...
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Plasma exosomes contain protein biomarkers valuable for the diagnosis of lung cancer
Accumulating evidence indicates that exosomal proteins are critical in diagnosing malignant tumors. To identify novel exosomal biomarkers for lung...
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Neonatal prophylactic antibiotics after preterm birth affect plasma proteome and immune development in pigs
BackgroundMost preterm infants receive antibiotics to prevent serious infections shortly after birth. However, prolonged antibiotic treatment...
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Autophagy Proteins and clinical data reveal the prognosis of polycystic ovary syndrome
ObjectiveWe aimed to investigate the significance of autophagy proteins and their association with clinical data on pregnancy loss in polycystic...
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Causal association between cardiovascular proteins and membranous nephropathy: a bidirectional Mendelian randomization
PurposeMultiple circulating proteins have been reported to participate in human diseases. However, the association between cardiovascular proteins...
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Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study
Background and aimsAtherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics,...
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Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria
PurposeMalaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites, mainly in tropical and subtropical countries. Plasmodium...
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Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction
To identify plasma proteins that mirror current and predict future remodeling after myocardial infarction (MI), we retrospectively interrogated...
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Upregulation of caveolae-associated structural proteins in the hair follicle bulge of lichen planopilaris and frontal fibrosing alopecia
Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are primary cicatricial alopecia that cause a major impact on quality of life due to...
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Effect of plasma exosomes on endothelial cell tight junction proteins in SLE patients with immune thrombocytopenia
ObjectivesTo study the expression of exosomes in peripheral blood of systemic lupus erythematosus (SLE) immune thrombocytopenia patients with and...
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Differential expression of coagulation pathway-related proteins in diabetic urine exosomes
BackgroundCoagulation function monitoring is important for the occurrence and development of diabetes. A total of 16 related proteins are involved in...
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Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders
Psychiatric disorders are highly heritable yet polygenic, potentially involving hundreds of risk genes. Genome-wide association studies have...
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Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis
Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates...
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Detecting and exploring kidney-derived extracellular vesicles in plasma
BackgroundExtracellular vesicles (EVs) have received considerable attention as ideal biomarkers for kidney diseases. Most reports have focused on...
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Emicizumab-mediated hemostatic function assessed by thrombin generation assay in an in vitro model of factor VIII-depleted thrombophilia plasma
Patients with hemophilia A (PwHA) may have concurrent deficiency of representative anticoagulant proteins, protein (P)C, PS, and antithrombin (AT),...
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Genetically Determined Levels of mTOR-Dependent Circulating Proteins and Risk of Multiple Sclerosis
BackgroundResults from observational studies indicate an association between circulating levels of mammalian target of rapamycin (mTOR)-dependent...
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Understanding the Complex Interactions between Coffee, Tea Intake and Neurologically Relevant Tissues Proteins in the Development of Anxiety and Depression
ObjectivesCoffee and tea intake might be associated with psychiatry diseases. However, it is unclear whether the effect of coffee/tea on anxiety and...
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ET1 acts as a potential plasma biomarker and therapeutic target in deep venous thrombosis rat model
Deep venous thrombosis (DVT) is the third leading cause of death in cardiovascular disease, following heart attacks and strokes. Early diagnosis and...
