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Molekulare Netzwerke von Hypoxie und neuronaler Apoptose in der Cochlea
BackgroundIn organotypic cultures, the modiolus (MOD) region of newborn rats shows a fourfold higher rate of cell death than the organ of Corti (OC)....
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PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids
Crucial decisions involving cell fate and connectivity that shape the distinctive development of the human brain occur in the embryonic and fetal...
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Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior
Pianp (also known as Leda-1) is a type I transmembrane protein with preferential expression in the mammalian CNS. Its processing is characterized by...
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Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines
Risk factors for hypertension consist of lifestyle and genetic factors. Family history and twin studies have yielded heritability estimates of BP in...
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Barriers and facilitators for the management of vertigo: a qualitative study with primary care providers
BackgroundAlthough the management of patients presenting with vertigo and dizziness in primary care has been reported to be inefficient, little is...
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Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP
Mutations in the microtubule-associated protein tau ( MAPT ) gene cause autosomal dominant frontotemporal lobar degeneration with tau inclusions...
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Transcriptome level analysis in Rett syndrome using human samples from different tissues
The mechanisms of neuro-genetic disorders have been mostly investigated in the brain, however, for some pathologies, transcriptomic analysis in...
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Barriers to and Facilitators of Alcohol Use Disorder Pharmacotherapy in Primary Care: A Qualitative Study in Five VA Clinics
BackgroundThree medications are FDA-approved and recommended for treating alcohol use disorders (AUD) but they are not offered to most patients with...
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Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment
Recent genome-wide association studies identified over 100 genetic loci that significantly associate with schizophrenia (SZ). A top candidate gene, ZNF804A...
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Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues
The pre-B lymphocyte protein 3 (VPREB3) is expressed during B cell differentiation and in subsets of mature B lymphocytes and is mainly found in bone...
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DNA hypermethylation of CD3+ T cells from cord blood of infants exposed to intrauterine growth restriction
Aims/hypothesisIntrauterine growth restriction (IUGR) is associated with increased susceptibility to obesity, metabolic syndrome and type 2 diabetes....
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Resuscitation of a dead cardiomyocyte
Although cardiac resuscitation can revive the whole body, the mechanisms are unclear. To this end, we propose that reviving a dead/dysfunctional...
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Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin
Carcinoma of unknown primary, wherein metastatic disease is present without an identifiable primary site, accounts for ~3–5% of all cancer diagnoses....
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SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival
MACC1 (metastasis associated in colon cancer 1) is a prognostic biomarker for tumor progression, metastasis and survival of a variety of solid...
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Generation of functional human serotonergic neurons from fibroblasts
The brain’s serotonergic system centrally regulates several physiological processes and its dysfunction has been implicated in the pathophysiology of...
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Spatial regulation of gene expression during growth of articular cartilage in juvenile mice
Background:In juvenile mammals, the epiphyses of long bones grow by chondrogenesis within the articular cartilage. A better understanding of the...
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Genomic structural variants are linked with intellectual disability
Mutations in more than 500 genes have been associated with intellectual disability (ID) and related disorders of cognitive function, such as autism...
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Modulation of behavioral networks by selective interneuronal inactivation
Gamma-aminobutyric acid (GABA)-ergic disturbances are hallmark features of schizophrenia and other neuropsychiatric disorders and encompass multiple...
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Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia
The underlying pathology of schizophrenia (SZ) is likely as heterogeneous as its symptomatology. A variety of cortical and subcortical regions,...
