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Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
One of the critical unmet medical needs in schizophrenia is the treatment for cognitive deficits. However, the neural circuit mechanisms of them...
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MRI findings of malignant transformation arising from mature cystic teratoma of the ovary: comparison with benign mature cystic teratoma
ObjectiveThis study aimed to evaluate the efficacy of MRI findings to differentiate malignant transformation arising from mature cystic teratoma...
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Increased CO2 levels in the operating room correlate with the number of healthcare workers present: an imperative for intentional crowd control
The air in an operating room becomes more contaminated as the occupancy of the room increases. Individuals residing in a room can potentially emit...
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Comparative performance of contact plate metod and swab method for surface microbial contamination on medical fabrics
BackgroundThe contact plate method is widely accepted and used in various fields where hygiene and contamination levels are crucial. Evidence...
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Access block and overcrowding at the emergency department at Tupua Tamasese Meaole Hospital in Samoa
BackgroundAccess block and overcrowding are known to adversely impact on patient outcomes, service delivery, and patient experiences within emergency...
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Increasing and sustaining discharges by noon – a multi-year process improvement project
High hospital occupancy degrades emergency department performance by increasing wait times, decreasing patient satisfaction, and increasing patient...
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Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the consecutive stages of the COVID-19 pandemic in the Netherlands, an update
BackgroundPreviously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during the final upsurge of...
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HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype
Adolescent binge drinking increases Toll-like receptor 4 (TLR4), receptor for advanced glycation end products (RAGE), the endogenous TLR4/RAGE...
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A positron emission tomography occupancy study of brexpiprazole at dopamine D2 and D3 and serotonin 5-HT1A and 5-HT2A receptors, and serotonin reuptake transporters in subjects with schizophrenia
The objective of this study (NCT01854944) was to assess D 2 /D 3 , 5-HT 1A , 5-HT 2A and serotonin transporter (SERT) occupancies of brexpiprazole in adult...
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Comparative analysis of discoid lateral meniscus size: a distinction between symptomatic and asymptomatic cases
PurposeThis study evaluated the differences in meniscal sizes and occupancy between symptomatic and asymptomatic patients diagnosed with discoid...
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Housing typologies and asthma: a sco** review
Asthma is related to triggers within the home. Although it is recognised that triggers likely occur due to characteristics of housing, these...
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Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy
Selective serotonin reuptake inhibitors (SSRIs) and internet-based cognitive behavioral therapy (ICBT) are recommended treatments of social anxiety...
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Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICU quality data from 2015 to 2020
This study aimed to explore key quality control factors that affected the prognosis of intensive care unit (ICU) patients in Chinese mainland over...
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Postoperative follow-up of submacular hemorrhage displacement treated with vitrectomy and subretinal injection of tissue plasminogen activator: ultrawide-field fundus autofluorescence imaging in gas-filled eyes
PurposeTo investigate the utility of Optos ultrawide-field fundus autofluorescence (UWF-FAF) imaging for postoperative follow-up of gas-filled eyes...
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Disrupted brain state dynamics in opioid and alcohol use disorder: attenuation by nicotine use
Substance use disorder (SUD) is a chronic relapsing disorder with long-lasting changes in brain intrinsic networks. While most research to date has...
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Automatic Forecast of Intensive Care Unit Admissions: The Experience During the COVID-19 Pandemic in Italy
The experience of the COVID-19 pandemic showed the importance of timely monitoring of admissions to the ICU admissions. The ability to promptly...
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders....
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Recursive neural networks in hospital bed occupancy forecasting
BackgroundEfficient planning of hospital bed usage is a necessary condition to minimize the hospital costs. In the presented work we deal with the...
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Efficiency of hospitals in COVID-19 era: a case study of an affected country
BackgroundThe COVID-19 pandemic has affected all aspects of human life and society and has damaged the global economy. Health systems and hospitals...
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The effect of time-varying capacity utilization on 14-day in-hospital mortality: a retrospective longitudinal study in Swiss general hospitals
BackgroundHigh bed-occupancy (capacity utilization) rates are commonly thought to increase in-hospital mortality; however, little evidence supports a...
