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Nitro-fatty acids: mechanisms of action, roles in metabolic diseases, and therapeutics
Nitro-fatty acids (NO 2 -FAs) are a class of bioactive lipids that mediate metabolic, anti-oxidative stress, anti-inflammatory, and other signaling...
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Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction
BackgroundMyocardial infarction remains a disease with high morbidity and death rate among cardiovascular diseases. Macrophages are abundant immune...
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A Practical Approach to the Management of Residual Cardiovascular Risk: United Arab Emirates Expert Consensus Panel on the Evidence for Icosapent Ethyl and Omega-3 Fatty Acids
PurposePatients with hyperlipidemia treated with statins remain at a residual cardiovascular (CV) risk. Omega-3 polyunsaturated fatty acids hold the...
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Serial change in perfusion–metabolism mismatch after coronary artery bypass grafting
ObjectiveMyocardial ischemia is known to suppress fatty acid metabolism and favor glucose metabolism. However, changes in myocardial metabolism after...
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FSTL3 partially mediates the association of increased nonalcoholic fatty liver disease fibrosis risk with acute myocardial infarction in patients with type 2 diabetes mellitus
BackgroundThe study aimed to investigate an association of increased liver fibrosis with acute myocardial infarction (AMI), and to investigate the...
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Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK
BackgroundAMPK is considered an important protein signaling pathway that has been shown to exert prominent cardioprotective effects on the...
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Network Pharmacology and Experimental Validation to Explore Mechanism of Tetrahydropalmatine on Acute Myocardial Ischemia
ObjectiveTo explore the potential molecular mechanism of tetrahydropalmatine (THP) on acute myocardial ischemia (AMI).
MethodsFirst, the target...
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MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus
Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients, characterized by a multifaceted pathogenesis and limited...
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Design and rationale for a comparison study of Olmesartan and Valsartan On myocardial metabolism In patients with Dilated cardiomyopathy (OVOID) trial: study protocol for a randomized controlled trial
BackgroundDilated cardiomyopathy (DCMP) is characterized by ventricular chamber enlargement and systolic dysfunction which may cause heart failure....
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Effects of obstructive sleep apnea on myocardial injury and dysfunction: a review focused on the molecular mechanisms of intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH) and is strongly associated with adverse cardiovascular outcomes....
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Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets
Critical illness is characterized by a hypercatabolic response encompassing endocrine and metabolic alterations. Not only the uptake, synthesis and...
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Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor...
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Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicity
BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease showing a rising prevalence globally. Genetic...
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The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats
BackgroundSodium-glucose cotransporter (SGLT)2 inhibitors have displayed beneficial effects on the cardiovascular system in diabetes mellitus (DM)...
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Reduction of myocardial lipid content assessed by H1 magnetic resonance spectroscopy in dyslipidemic patients after statins
BackgroundDyslipidemia is one of the main modifiable risk factors for cardiovascular diseases, which accounts for one third of total deaths...
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Omega-3 Fatty Acids in Cardiovascular Disease and Diabetes: a Review of Recent Evidence
Purpose of ReviewOmega-3 fatty acids (n-3 FA) lower triglycerides, have anti-inflammatory properties, and improve metabolism. Clinical evidence of...
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Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression
ObjectiveDiabetic cardiomyopathy (DCM) represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with...
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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various...
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Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease
BackgroundNonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the...
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Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
BackgroundThe heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and...
