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Massive adrenocortical carcinoma presenting as peripheral edema: a case report
BackgroundAdrenocortical carcinoma is a rare, but potentially lethal, malignancy that is usually detected as an incidental finding on abdominal...
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Pregnancy in patients with adrenocortical carcinoma: a case-based discussion
Although adrenocortical carcinoma (ACC) during pregnancy is rare, a retrospective review of a case series at our hospital revealed that almost one...
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Oncocytic adrenocortical neoplasm of borderline uncertain malignant potential diagnosed after robot-assisted adrenalectomy case report
BackgroundAdrenal incidentalomas are radiologically discovered tumors that represent a variety of pathologies, with the diagnosis clinched only on...
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Mitotane (Lysodren®) in der Therapie des Nebennierenrindenkarzinoms
Mitotane, or o,p’-DDD (European tradename: Lysodren®, HRA Pharma, Paris, France), is an orphan drug for the adjuvant therapy of adrenocortical...
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Supportive therapies in patients with advanced adrenocortical carcinoma submitted to standard EDP-M regimen
PurposeThe management of patients with advanced/metastatic adrenocortical carcinoma (ACC) is challenging, EDP-M (etoposide, doxorubicin, cisplatin...
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The effects of mitotane and 1α,25-dihydroxyvitamin D3 on Wnt/beta-catenin signaling in human adrenocortical carcinoma cells
PurposeMitotane is the only chemotherapeutic agent available for the treatment of adrenocortical carcinoma (ACC), however, the anti-neoplastic...
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High expression of GMNN predicts malignant progression and poor prognosis in ACC
BackgroundAdrenocortical carcinoma (ACC) is a rare endocrine neoplasm, which is characterized by poor prognosis and high recurrence rate. Novel and...
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Challenges in the diagnosis of the enigmatic primary adrenal leiomyosarcoma: two case reports and review of the literature
BackgroundPrimary adrenal leiomyosarcoma is a rare and aggressive mesenchymal tumor derived from the smooth muscle wall of a central adrenal vein or...
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Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future
The introduction of Ki67 immunohistochemistry in the work-up of neuroendocrine neoplasms (NENs) has opened a new approach for their diagnosis and...